{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:17:04Z","timestamp":1789017424775,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Data on the effect of booster SARS\u2010CoV\u20102 vaccination are mainly focused on humoral immunogenicity, while the kinetics of vaccine\u2010induced cellular response and its correlation with effectiveness in hematologic patients are less explored. Our aim was to evaluate the longitudinal cellular and humoral immunogenicity induced by two and three doses of the mRNA\u20101273 SARS\u2010CoV\u20102 vaccine in 270 patients with hematologic malignancies, and its relationship with the severity of breakthrough SARS\u2010CoV\u20102 infection. Results indicate that at 23\u2009weeks after the second dose, the seroconversion rate declined from 68.5% to 59.3%, with a reduction in median anti\u2010S titers from 1577 to 456\u2009BAU\/mL, mainly in patients over 65\u2009years of age or chronic lymphocytic leukemia (CLL) patients undergoing active therapy. Cellular immunogenicity, however, remained positive in 84.4% of cases. A third vaccine dose seroconverted 42.7% (41\/96) and triggered cellular response in 36.7% (11\/30) of previously negative patients. Notably, only 7.2% (15\/209) of patients failed to develop both humoral and cellular response. Active therapy, anti\u2010CD20 antibodies, lymphopenia, hypogammaglobulinemia, and low CD19\n                    <jats:sup>+<\/jats:sup>\n                    cell count were associated with poor humoral response, while active disease, GvHD immunosuppressive therapy, lymphopenia, and low CD3\n                    <jats:sup>+<\/jats:sup>\n                    , CD4\n                    <jats:sup>+<\/jats:sup>\n                    , CD56\n                    <jats:sup>+<\/jats:sup>\n                    cell count determined an impaired cellular response. After 13.8\u2009months of follow\u2010up, the incidence of SARS\u2010CoV\u20102 infection was 24.8% (67\/270), including 6 (9%) severe\/critical cases associated with a weaker cellular (median interferon gamma (IFN\u2010\u03b3) 0.19 vs. 0.35\u2009IU\/mL) and humoral response (median anti\u2010S titer &lt;4.81 vs. 788\u2009BAU\/mL) than asymptomatic\/mild cases. In conclusion, SARS\u2010CoV\u20102 booster vaccination improves humoral response and COVID\u201019 severity is associated with impaired vaccine\u2010induced immunogenicity.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26951","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:29:41Z","timestamp":1683516581000},"page":"1204-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Kinetics of cellular and humoral immunogenicity and effectiveness of\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 booster vaccination in hematologic neoplasms"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-8562","authenticated-orcid":false,"given":"Moraima","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Servei d'Hematologia, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Bellaterra, Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candela","family":"Fern\u00e1ndez\u2010Naval","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vall d'Hebron Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-4605","authenticated-orcid":false,"given":"V\u00edctor","family":"Navarro","sequence":"additional","affiliation":[{"name":"Oncology Data Science (ODysSey) Group Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Novoa","sequence":"additional","affiliation":[{"name":"Servei d'Hematologia, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Martinez\u2010Gallo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Department of Cell Biology, Physiology and Immunology Autonomous University of Barcelona (UA)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Bellaterra, Barcelona Spain"},{"name":"Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vall d'Hebron Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vall d'Hebron Hospital Universitari 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