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Myeloid\/lymphoid neoplasms with eosinophilia (M\/LN\u2010eo) and gene rearrangements have been renamed as M\/LN\u2010eo with tyrosine kinase gene fusions (M\/LN\u2010eo\u2010TK). The category has been expanded to include <jats:italic>ETV6::ABL1<\/jats:italic> and <jats:italic>FLT3<\/jats:italic> fusions, and to accept <jats:italic>PCM1::JAK2<\/jats:italic> and its genetic variants as formal members. The overlaps and differences between M\/LN\u2010eo\u2010TK and <jats:italic>BCR::ABL1<\/jats:italic>\u2010like B\u2010lymphoblastic leukemia (ALL)\/de novo T\u2010ALL sharing the same genetic lesions are addressed. Besides genetics, ICC for the first time has introduced bone marrow morphologic criteria in distinguishing idiopathic hypereosinophilia\/hypereosinophilic syndrome from chronic eosinophilic leukemia, not otherwise specified. The major diagnostic criteria for systemic mastocytosis (SM) in the ICC remain largely based on morphology, but several minor modifications\/refinements have been made in criteria related to diagnosis, subclassification, and assessment of disease burden (B\u2010 and C\u2010findings). This review is to focus on the ICC updates related to these disease entities, illustrated through changes related to morphology, molecular genetics, clinical features, prognosis, and treatment. Two practical algorithms are provided in navigating through the diagnosis and classification systems of hypereosinophilia and SM.<\/jats:p>","DOI":"10.1002\/ajh.26966","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T04:21:48Z","timestamp":1686198108000},"page":"1286-1306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The international consensus classification of eosinophilic disorders and systemic mastocytosis"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-9911","authenticated-orcid":false,"given":"Sa A.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston Texas 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