{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:56:04Z","timestamp":1790034964299,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Disease Overview<\/jats:title>\n                    <jats:p>Approximately one\u2010fourth of primary cutaneous lymphomas are B\u2010cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B\u2010cell lymphoma, leg type (PCDLBCL, LT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis<\/jats:title>\n                    <jats:p>Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B\u2010cell lymphomas from systemic B\u2010cell lymphomas with secondary skin involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk\u2010Stratification<\/jats:title>\n                    <jats:p>Disease histopathology remains the most important prognostic determinant in primary cutaneous B\u2010cell lymphomas. Both PCFCL and PCMZL are indolent lymphomas that infrequently disseminate to extracutaneous sites and are associated with 5\u2010year survival rates that exceed 95%. In contrast, PCDLBCL, LT is an aggressive lymphoma with an inferior prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk\u2010Adapted Therapy<\/jats:title>\n                    <jats:p>PCFCL and PCMZL patients with solitary or relatively few skin lesions may be effectively managed with local radiation therapy. While single\u2010agent rituximab may be employed for patients with more widespread skin involvement, multiagent chemotherapy is rarely appropriate. In contrast, management of patients with PCDLBCL, LT is comparable to the management of patients with systemic DLBCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.26968","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T06:58:20Z","timestamp":1684738700000},"page":"1326-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Cutaneous B\u2010cell lymphomas: 2023 update on diagnosis, risk\u2010stratification, and management"],"prefix":"10.1002","volume":"98","author":[{"given":"Alexandra C.","family":"Hristov","sequence":"first","affiliation":[{"name":"Departments of Pathology and Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trilokraj","family":"Tejasvi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-0760","authenticated-orcid":false,"given":"Ryan A.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of Michigan Cancer Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184168"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.393"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-054601"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14549"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01543.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1594"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb00766.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371768"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.3922"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6396"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002469"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03265-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.09.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.9.1144"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.10.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10104"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0041-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.01.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153812"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.265"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.821"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.018"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.07.008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01318.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.01003.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200009000-00012"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.281002.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001363"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f72835"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132415"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa116"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03186-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015854"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0599-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13464"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12745"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000282"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001186"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07159.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.137"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6285"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.019"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3955"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22720.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.357"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3602"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.18039"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw214"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-152850"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2471"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10902.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754221126119"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194787"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09798.x"},{"key":"e_1_2_7_63_1","first-page":"391","article-title":"Topical imiquimod as treatment for different kinds of cutaneous lymphoma","volume":"16","author":"Coors EA","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181b8c377"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000738"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/229255031101900208"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00544.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1787-0"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2015.6067"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30225-4"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.03.1516"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2919"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T03:54:51Z","timestamp":1739246091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ajh.26968"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26968","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]},"assertion":[{"value":"2023-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}