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Here, we investigated the kinetics of immune cell and antibody responses in blood during COVID\u201019 of MBL<jats:sup>lo<\/jats:sup> versus non\u2010MBL patients. For this study, we analyzed the kinetics of immune cells in blood of 336 COVID\u201019 patients (74 MBL<jats:sup>lo<\/jats:sup> and 262 non\u2010MBL), who had not been vaccinated against SARS\u2010CoV\u20102, over a period of 43\u2009weeks since the onset of infection, using high\u2010sensitivity flow cytometry. Plasma levels of anti\u2010SARS\u2010CoV\u20102 antibodies were measured in parallel by ELISA. Overall, early after the onset of symptoms, MBL<jats:sup>lo<\/jats:sup> COVID\u201019 patients showed increased neutrophil, monocyte, and particularly, plasma cell (PC) counts, whereas eosinophil, dendritic cell, basophil, and lymphocyte counts were markedly decreased in blood of a variable percentage of samples, and with a tendency toward normal levels from week +5 of infection onward. Compared with non\u2010MBL patients, MBL<jats:sup>lo<\/jats:sup> COVID\u201019 patients presented higher neutrophil counts, together with decreased pre\u2010GC B\u2010cell, dendritic cell, and innate\u2010like T\u2010cell counts. Higher PC levels, together with a delayed PC peak and greater plasma levels of anti\u2010SARS\u2010CoV\u20102\u2010specific antibodies (at week +2 to week +4) were also observed in MBL<jats:sup>lo<\/jats:sup> patients. In summary, MBL<jats:sup>lo<\/jats:sup> COVID\u201019 patients share immune profiles previously described for patients with severe SARS\u2010CoV\u20102 infection, associated with a delayed but more pronounced PC and antibody humoral response once compared with non\u2010MBL patients.<\/jats:p>","DOI":"10.1002\/ajh.27119","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T16:44:21Z","timestamp":1696437861000},"page":"1909-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune cell kinetics and antibody response in <scp>COVID<\/scp>\u201019 patients with low\u2010count monoclonal B\u2010cell lymphocytosis"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-9849","authenticated-orcid":false,"given":"Guillermo","family":"Oliva\u2010Ariza","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Program, Cancer Research Center (IBMCC, CSIC \u2013 University of Salamanca); 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Cytometry Service, NUCLEUS University of Salamanca (Universidad de Salamanca)  Salamanca Spain"},{"name":"Department of Medicine University of Salamanca (Universidad de Salamanca)  Salamanca Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL)  Salamanca Spain"},{"name":"Biomedical Research Networking Centre Consortium of Oncology (CIBERONC) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Salamanca (Universidad de Salamanca)  Salamanca Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL)  Salamanca Spain"},{"name":"Department of Internal Medicine University Hospital of Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"P\u00e9rez\u2010Pons","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Program, Cancer Research Center (IBMCC, CSIC \u2013 University of Salamanca); 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