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The effect differed by conditioning\u2014partly related to the differences in the recipient age in myeloablative (MAC; median 46\u2009years) versus reduced\u2010intensity\/non\u2010myeloablative conditioning (RIC\/NMA; median 61\u2009years) groups. With MAC (<jats:italic>n<\/jats:italic>\u2009=\u2009320), donor age had no impact on acute graft\u2010versus\u2010host disease (GVHD), but older donors were associated with a significantly higher risk of chronic GVHD (hazard ratio [HR]: 1.6, 95% confidence interval [CI]: 1.10\u20132.30, <jats:italic>p<\/jats:italic>\u2009=\u2009.02) independent of recipient age and other factors. Donor age had no impact on either relapse or non\u2010relapse mortality (NRM). The impact of donor\/recipient age on overall survival changed over time. Older donors were associated with significantly higher late overall mortality (&gt;6\u2009months) in younger recipients (\u2264\u200950\u2009years; HR: 2.2, 95% CI: 1.03\u20134.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.04) but not older recipients. With RIC\/NMA (<jats:italic>n<\/jats:italic>\u2009=\u2009470), neither recipient's nor donor's age influenced the risk of GVHD. Donor age had no significant impact on the risk of relapse, but older donors were associated with a significantly higher risk of NRM (HR: 1.6, 95% CI: 1.02\u20132.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.04) independent of recipient age. Older donor age was associated with significantly higher late overall mortality (&gt;9\u2009months) in older recipients (&gt;50\u2009years; HR: 1.66, 95% CI: 1.0\u20132.67; <jats:italic>p<\/jats:italic>\u2009=\u2009.049) but not in younger recipients. Donor selection based on donor age may require a tailored approach for a particular recipient.<\/jats:p>","DOI":"10.1002\/ajh.27126","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:15:57Z","timestamp":1697631357000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of donor age in patients with <scp>acute myeloid leukemia<\/scp> undergoing haploidentical <scp>hematopoietic cell transplantation<\/scp> vary by conditioning intensity and recipient age"],"prefix":"10.1002","volume":"99","author":[{"given":"Rima M.","family":"Saliba","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Kanakry","sequence":"additional","affiliation":[{"name":"Center for Immuno\u2010Oncology, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahinaz","family":"Gadalla","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partow","family":"Kebriaei","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoun","family":"Rezvani","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Champlin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Shpall","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8078-8579","authenticated-orcid":false,"given":"Daniel","family":"Weisdorf","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-544X","authenticated-orcid":false,"given":"Rohtesh 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