{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:36:01Z","timestamp":1790609761619,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For elderly frail patients with diffuse large B\u2010cell lymphoma (DLBCL), an attenuated chemo\u2010immunotherapy strategy of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R\u2010miniCHOP) was introduced as a treatment option as from 2014 onward in the Netherlands. Although R\u2010miniCHOP is more tolerable, reduction of chemotherapy could negatively affect survival compared to R\u2010CHOP. The aim of this analysis was to assess survival of patients treated with R\u2010miniCHOP compared to R\u2010CHOP. DLBCL patients \u226565\u2009years, newly diagnosed in 2014\u20132020, who received \u22651\u2009cycle of R\u2010miniCHOP or R\u2010CHOP were identified in the Netherlands Cancer Registry, with survival follow\u2010up through 2022. Patients were propensity\u2010score\u2010matched for baseline characteristics. Main endpoints were progression\u2010free survival (PFS), overall survival (OS), and relative survival (RS). The use of R\u2010miniCHOP in DLBCL increased from 2% in 2014 to 15% in 2020. In total, 384 patients treated with R\u2010miniCHOP and 384 patients treated with R\u2010CHOP were included for comparison (median age; 81\u2009years, stage 3\u20134; 68%). The median number of R\u2010(mini)CHOP cycles was 6 (range, 1\u20138). The 2\u2010year PFS, OS and RS were inferior for patients treated with R\u2010miniCHOP compared to R\u2010CHOP (PFS 51% vs. 68%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01; OS 60% vs. 75%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01; RS 69% vs. 86%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). In multivariable analysis, patients treated with R\u2010miniCHOP had higher risk of all\u2010cause mortality compared to patients treated with R\u2010CHOP (HR 1.73; 95%CI, 1.39\u20132.17). R\u2010miniCHOP is effective for most elderly patients. Although survival is inferior compared to R\u2010CHOP, the use of R\u2010miniCHOP as initial treatment is increasing. Therefore, fitness needs to be carefully weighed in treatment selection.<\/jats:p>","DOI":"10.1002\/ajh.27151","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T14:58:03Z","timestamp":1701183483000},"page":"216-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<scp>R\u2010miniCHOP<\/scp> versus <scp>R\u2010CHOP<\/scp> in elderly patients with diffuse large B\u2010cell lymphoma: A propensity matched population\u2010based study"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-6403","authenticated-orcid":false,"given":"D.","family":"Al\u2010Sarayfi","sequence":"first","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E. D.","family":"Chamuleau","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam UMC Locatie VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Hematology Reinier de Graaf Gasthuis  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"van Rijn","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical Center Leeuwarden  Leeuwarden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Hematology Jeroen Bosch Hospital  Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Deenik","sequence":"additional","affiliation":[{"name":"Department of Hematology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Huls","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mous","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-6256","authenticated-orcid":false,"given":"J. S. P.","family":"Vermaat","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diepstra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam UMC Locatie VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"van Meerten","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nijland","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.94"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004295"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70069-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv304"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)30171-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-149019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/22.3.369"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_9_11_1","volume-title":"Instructions to IBM 650 programmers in processing survival computations. Methodological note No. 10. End results evaluation section","author":"Ederer F","year":"1959"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2768-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30054-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186569"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02465"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02666"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01525-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.473"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03775-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80706-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746120-00005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02403"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00889-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-136255"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T06:49:10Z","timestamp":1705733350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ajh.27151"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27151","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"2023-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}