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Not all patients make it to the CART infusion phase due to disease progression. Among those who receive CART, a significant number of patients experience life\u2010threatening cytokine release syndrome toxicity, and less than half maintain a durable response with the majority relapsing in pre\u2010existing sites of disease present pre\u2010CART. Radiation therapy stands as a promising peri\u2010CART and salvage treatment that can improve the outcomes of these patients. Evidence suggests that bridging radiotherapy prior to CART controls the disease during the manufacturing period, augments response rates and local control, cytoreduces\/debulks the disease and decreases the severity of cytokine release syndrome, and may prolong disease\u2010free intervals and survival especially in patients with bulky disease. Consolidative radiotherapy for residual post\u2010CART disease alters the pattern of relapse and improves local recurrence\u2010free and progression\u2010free survivals. Salvage radiotherapy for relapsed post\u2010CART disease has favorable survival outcomes when delivered comprehensively for patients with limited relapsed disease and palliates symptoms for patients with diffuse relapsed disease. The biology of the disease during the peri\u2010CART period is poorly understood, and further studies investigating the optimal timing and dosing of radiation therapy (RT) are needed. In this review, we tackle the most significant challenges of CART, review and propose how RT can help mitigate these challenges, and provide The Mayo Clinic experts' approach on incorporating RT with CART.<\/jats:p>","DOI":"10.1002\/ajh.27155","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T17:15:10Z","timestamp":1699722910000},"page":"124-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incorporating radiation with anti\u2010CD19 chimeric antigen receptor T\u2010cell therapy for relapsed\/refractory non\u2010Hodgkin lymphoma: A multicenter consensus approach"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-4771","authenticated-orcid":false,"given":"Omran","family":"Saifi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Lester","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Rule","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Experimental Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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