{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:28:41Z","timestamp":1789522121601,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1002\/ajh.27161","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T18:50:30Z","timestamp":1700851830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Phase Ib study of sabatolimab (\n                    <scp>MBG453<\/scp>\n                    ), a novel immunotherapy targeting\n                    <scp>TIM\u20103<\/scp>\n                    antibody, in combination with decitabine or azacitidine in high\u2010 or very high\u2010risk myelodysplastic syndromes"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-4115","authenticated-orcid":false,"given":"Andrew M.","family":"Brunner","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo","family":"Porkka","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Knapper","sequence":"additional","affiliation":[{"name":"School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Traer","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Scholl","sequence":"additional","affiliation":[{"name":"University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-2482","authenticated-orcid":false,"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-040X","authenticated-orcid":false,"given":"Norbert","family":"Vey","sequence":"additional","affiliation":[{"name":"Institut Paoli\u2010Calmettes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wermke","sequence":"additional","affiliation":[{"name":"TU Dresden, NCT\/UCC Early Clinical Trial Unit  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J. W. M.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Narayan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Fleming","sequence":"additional","affiliation":[{"name":"The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Loo","sequence":"additional","affiliation":[{"name":"The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tovar","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kontro","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Ottmann","sequence":"additional","affiliation":[{"name":"School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purushotham","family":"Naidu","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Sun","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Han","sequence":"additional","affiliation":[{"name":"Cure Ventures  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roisin","family":"White","sequence":"additional","affiliation":[{"name":"Novartis Ireland Limited  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Sabatos\u2010Peyton","sequence":"additional","affiliation":[{"name":"Larkspur Biosciences  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Steensma","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael L.","family":"Rinne","sequence":"additional","affiliation":[{"name":"Blueprint Medicines  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Borate","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-3298","authenticated-orcid":false,"given":"Andrew H.","family":"Wei","sequence":"additional","affiliation":[{"name":"The Peter MacCallum Cancer Centre and Royal Melbourne Hospital Walter and Eliza Hall Institute of Medical Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1349100"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.06.023"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.8135"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25684"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.14578"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21792"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70003-8"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000150"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25488"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000911"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0224-6"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100551108"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.014"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.07.011"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0180-3"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21492"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03626-9"},{"issue":"3","key":"e_1_2_3_20_1","article-title":"439\u2009Dual modes of action for anti\u2010TIM\u20103 antibody MBG453 in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): preclinical evidence for immune\u2010mediated and anti\u2010leukemic activity","volume":"8","author":"Sabatos\u2010Peyton C","year":"2020","journal-title":"J Immunother Cancer"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/immadv\/ltac019"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-137307"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12962"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4746"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146039"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01265-7"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.04.001"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S39536"},{"key":"e_1_2_3_30_1","doi-asserted-by":"crossref","unstructured":"SallmanDA Al MalkiMM AschAS et al.Magrolimab in combination with azacitidine for patients with untreated higher\u2010risk myelodysplastic syndromes (HR MDS): 5F9005 phase 1B study results. EHA 2022; June 9\u201317 2022; Vienna Austria.","DOI":"10.1016\/S2152-2650(22)00690-5"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.25.4235"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz253.028"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-158612"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4149"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T01:50:02Z","timestamp":1705715402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ajh.27161"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27161","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"2023-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}