{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:40:22Z","timestamp":1775194822661,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fludarabine\/busulfan and fludarabine\/melphalan are viable options as conditioning regimens. However, the optimal fludarabine\u2010based conditioning in cord blood transplantation (CBT) remains unclear. Therefore, this retrospective, registry\u2010based study aimed to analyze the impact of five fludarabine\u2010containing conditioning regimens on 1395 adult patients (median age, 61\u2009years) with acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia who underwent their first CBT. Treatment outcomes of fludarabine combined with melphalan (100\u2013140\u2009mg\/m<jats:sup>2<\/jats:sup>) and low\u2010dose total body irradiation (TBI; FM140T); melphalan (80\u201399\u2009mg\/m<jats:sup>2<\/jats:sup>) and TBI (FM80T); busulfan (12.8\u2009mg\/kg) and melphalan (FB4M); busulfan (12.8\u2009mg\/kg) and TBI (FB4T); and busulfan (6.4\u2009mg\/kg) and TBI (FB2T) were compared. The 3\u2010year survival rate was 67%, 53%, 44%, 36%, and 39%, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). The FM140T survival rate was the most favorable after adjusting for confounders, and the hazard ratios (vs. FM140T) for overall mortality were as follows: FM80T, 1.6 (95% confidence interval [CI], 1.2\u20132.2); FB4M, 2.1 (95% CI, 1.6\u20132.8); FB4T, 2.7 (95% CI, 2.0\u20133.7); and FB2T, 2.2 (95% CI, 1.6\u20133.1). The better survival observed with FM140T, regardless of the disease, disease risk, age, or transplant year, was attributed to the lower relapse rate and lower non\u2010relapse mortality (NRM) associated with fewer infectious deaths. Conversely, FB4T was associated with a higher relapse rate and higher NRM. The findings indicate that the outcomes of CBT in myeloid malignancies were highly dependent on both the alkylating agent and its dose in combination with fludarabine. Therefore, compared with fludarabine\/busulfan\u2010based conditioning, FM140T may be the preferred regimen.<\/jats:p>","DOI":"10.1002\/ajh.27172","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T16:31:45Z","timestamp":1704213105000},"page":"236-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of fludarabine\u2010based conditioning regimens in adult cord blood transplantation for myeloid malignancy: A retrospective, registry\u2010based study"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-4307","authenticated-orcid":false,"given":"Naoki","family":"Kurita","sequence":"first","affiliation":[{"name":"Department of Hematology, Institute of Medicine University of Tsukuba  Tsukuba 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