{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:00:19Z","timestamp":1788184819975,"version":"build-2803163510"},"reference-count":205,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Disease Overview<\/jats:title><jats:p>Hairy cell leukemia (HCL) and HCL\u2010like disorders, including HCL variant (HCL\u2010V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogenous group of mature lymphoid B\u2010cell disorders characterized by the identification of hairy cells, a specific genetic profile, a different clinical course and the need for appropriate treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis<\/jats:title><jats:p>Diagnosis of HCL is based on morphological evidence of hairy cells, an HCL immunologic score of 3 or 4 based on the CD11c, CD103, CD123, and CD25 expression, the trephine biopsy which makes it possible to specify the degree of tumoral bone marrow infiltration and the presence of BRAF<jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> somatic mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Risk Stratification<\/jats:title><jats:p>Progression of patients with HCL is based on a large splenomegaly, leukocytosis, a high number of hairy cells in the peripheral blood, and the immunoglobulin heavy chain variable region gene mutational status. VH4\u201034 positive HCL cases are associated with a poor prognosis, as well as HCL with TP53 mutations and HCL\u2010V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment<\/jats:title><jats:p>Patients should be treated only if HCL is symptomatic. Chemotherapy with risk\u2010adapted therapy purine analogs (PNAs) are indicated in first\u2010line HCL patients. The use of chemo\u2010immunotherapy combining cladribine (CDA) and rituximab (R) represents an increasingly used therapeutic approach. Management of relapsed\/refractory disease is based on the use of BRAF inhibitors (BRAFi) plus R, MEK inhibitors (MEKi), recombinant immunoconjugates targeting CD22, Bruton tyrosine kinase inhibitors (BTKi), and Bcl\u20102 inhibitors (Bcl\u20102i). However, the optimal sequence of the different treatments remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajh.27240","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T08:50:31Z","timestamp":1709628631000},"page":"679-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hairy cell leukemia 2024: Update on diagnosis, risk\u2010stratification, and treatment\u2014Annual updates in hematological malignancies"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-9992","authenticated-orcid":false,"given":"Xavier","family":"Troussard","sequence":"first","affiliation":[{"name":"Laboratoire H\u00e9matologie CHU C\u00f4te de Nacre  Caen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-8225","authenticated-orcid":false,"given":"Elsa","family":"Ma\u00eetre","sequence":"additional","affiliation":[{"name":"Laboratoire H\u00e9matologie CHU C\u00f4te de Nacre  Caen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-018X","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Paillassa","sequence":"additional","affiliation":[{"name":"Service des Maladies du Sang CHU Angers  Angers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06769.x"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30445-X"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-051672"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00732.x"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.03.001"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-820381"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100236"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26881"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.07.003"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290021560"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu004"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.610011"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.143"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05261.x"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2015.10.014"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.05.003"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1908121"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-098848"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-857938"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011147"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04349-z"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2020.2020069"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13505"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7343"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0763"},{"issue":"1","key":"e_1_2_15_30_1","first-page":"57","article-title":"The immunophenotype of hairy cell leukemia (HCL). Proposal for a scoring system to distinguish HCL from B\u2010cell disorders with hairy or villous lymphocytes","volume":"14","author":"Matutes E","year":"1994","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21365"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2016.02.041"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14041050"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512830"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18224"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-689422"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16356-3"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15502"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021015066"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.11.021"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157780"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008004"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12735"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17890"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00215-6"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2828"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-643361"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-765107"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371179"},{"key":"e_1_2_15_51_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Piris MA","year":"2008"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-751024"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160192"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081904"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.62"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2020.10.003"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.294"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401721"},{"key":"e_1_2_15_59_1","first-page":"1","article-title":"Splenic diffuse red pulp lymphoma has a distinct pattern of somatic mutations amongst B\u2010cell malignancies","volume":"58","author":"Traverse\u2010Glehen A","year":"2016","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120910"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25601"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149162"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04010-4"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(99)00127-7"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01823-1"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1054"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01817-8"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1753045"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18980"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22253"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21252"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225326"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.07.002"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306220"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3884"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.012"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501548"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-747345"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12867"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402107"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031175"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001723449"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.11.012"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf588"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086556"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2015.09.006"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3945.bloodjournal88103945"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.3.873.873"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V118.21.1760.1760"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-014-0285-5"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-603100"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3737"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.9.3161"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19540"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.2.497.497"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024059"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-418434"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316737"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212449"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000980"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905833106"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502309"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.742525"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09837"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-749374"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-757823"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1177\/20363613211012929"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001926"},{"key":"e_1_2_15_109_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2017"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12824"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.957"},{"key":"e_1_2_15_112_1","first-page":"253","article-title":"Splenic diffuse red pulp small\u2010B cell lymphoma: toward the emergence of a new lymphoma entity","volume":"13","author":"Traverse\u2010Glehen A","year":"2012","journal-title":"Discov Med"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.330"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.975"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.04.005"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0893"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-01004-y"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09163.x"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.03.011"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2140-y"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0165"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0014"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12908"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0328-z"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2015.09.004"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.565093"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26287"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-1325-9"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14129"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02250"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.568650"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506583"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198401053100104"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.02.005"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01257-7"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25474"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2870"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1495"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.562575"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1848"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3219-z"},{"key":"e_1_2_15_142_1","first-page":"1046","article-title":"Efficacy of anti\u2010CD20 monoclonal antibodies (Mabthera) in patients with progressed hairy cell leukemia","volume":"86","author":"Lauria F","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02906136"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0014"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0630"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11564"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1159\/000270903"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007854"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-680074"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0646-y"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016183"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208958"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.540030"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76539"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01210-8"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-113135"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031298"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132800"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300074"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-803072"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0210-1"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1929959"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25243"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.6.1918"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.093"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400513"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428199909169620"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009688"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008990"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513257"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809058365"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.598319"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2216135"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2215613"},{"key":"e_1_2_15_176_1","first-page":"2366","article-title":"Splenectomy as initial therapy in twenty\u2010six patients with leukemic reticuloendotheliosis (hairy cell leukemia)","volume":"39","author":"Mintz U","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281754"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1752"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.565096"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005039"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1365853"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2810"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1239262"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2176"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024457"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25264"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013714"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000523"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-201731"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11378"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12429"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12839"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-843128"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17201"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000760\u2010z"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1160"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2454"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.638"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk030"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15777"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.06.001"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010019\u20100201\u20100"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102060"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2520-y"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.731599"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014760"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T11:16:30Z","timestamp":1714043790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":205,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ajh.27240"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27240","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,5]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}