{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:34:18Z","timestamp":1790260458360,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current guidelines suggest a 3\u2010month anticoagulant treatment course for isolated distal deep vein thrombosis (IDDVT), but shorter durations of treatment are frequently prescribed in clinical practice. We investigated whether a 6\u2010week treatment with low\u2010molecular\u2010weight heparin (LMWH) at intermediate dosage can be an effective and safe alternative to vitamin K antagonists (VKA) in patients with IDDVT (non\u2010inferiority trial). In a multicenter, open\u2010label, randomized trial, 260 outpatients with symptomatic IDDVT were randomly assigned to receive either LMWH followed by VKA for 12\u2009weeks or LMWH 1\u2009mg\/kg subcutaneously twice a day for 2\u2009weeks followed by 1\u2009mg\/kg subcutaneously once a day for 4\u2009weeks. The follow\u2010up was 6\u2009months and the primary endpoint was the composite measure of recurrent venous thromboembolism (VTE) defined as: recurrence or extension of IDDVT, proximal DVT, and pulmonary embolism (PE). The study was stopped prematurely due to slow recruiting rates. The primary efficacy outcome occurred in 14 patients receiving LMWH (10.8%) and in five patients receiving VKA (3.8%); risk difference was 0.069 (95% CI: 0.006\u20130.132), hazard ratio 2.8 (95% CI: 1.04\u20137.55). There was one PE in the VKA group and one proximal DVT in the LMWH group. IDDVT recurrence was 10.0% in the LMWH group versus 3.1% in the VKA group (<jats:italic>p<\/jats:italic>\u2009=\u2009.024). Two patients had clinically relevant bleedings (1.6%) in the LMWH group versus one (0.8%) in VKA group (<jats:italic>p<\/jats:italic>\u2009=\u2009.56). In conclusion, VKA for 12\u2009weeks seems superior to LMWH for 6\u2009weeks in reducing the risk of VTE recurrences in our cohort of outpatients with IDDVT.<\/jats:p>","DOI":"10.1002\/ajh.27255","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:15:30Z","timestamp":1708427730000},"page":"854-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Six\u2010week low\u2010molecular\u2010weight heparin versus 12\u2010week warfarin for calf deep vein thrombosis: A randomized, prospective, open\u2010label study"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-4676","authenticated-orcid":false,"given":"Michelangelo","family":"Sartori","sequence":"first","affiliation":[{"name":"Angiology and Blood Coagulation Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Iotti","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Unit \u2013 AUSL\u2010IRCCS  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Camporese","sequence":"additional","affiliation":[{"name":"General Medicine Unit, Thrombotic and Haemorrhagic Disorders Unit, Department of Internal Medicine University Hospital of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Siragusa","sequence":"additional","affiliation":[{"name":"Haematology Unit, Thrombosis and Haemostasis Reference Regional Center University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Imberti","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Center, Department of Internal Medicine Hospital of Piacenza  Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Bucherini","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine AUSL Romagna  Faenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Corradini","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Unit \u2013 AUSL\u2010IRCCS  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Prandoni","sequence":"additional","affiliation":[{"name":"Arianna Foundation on Anticoagulation  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ghirarduzzi","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Unit \u2013 AUSL\u2010IRCCS  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27077"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.056"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-016-0594-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00318.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.07.022"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"68","article-title":"Isolated distal deep vein thrombosis: efficacy and safety of a protocol of treatment. 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