{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:11:55Z","timestamp":1780398715153,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151494 to KRM"],"award-info":[{"award-number":["R01HL151494 to KRM"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["R03DK124746 to KRM"],"award-info":[{"award-number":["R03DK124746 to KRM"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with peripheral artery disease (PAD) have poorer limb salvage outcomes in spite of having lower risk factors for vascular disease than their male counterparts. Mono antiplatelet therapy with aspirin is the cornerstone of medical treatment for PAD to reduce the risk of arterial thrombosis, but platelets in women may have a variable response to this standard of care compared to men. Viscoelastic assays, such as thromboelastography with platelet mapping (TEG\u2010PM), have been utilized to identify prothrombotic states and may provide insight into a patient's real\u2010time coagulation profile and their response to specific antiplatelet medications. The aim of this prospective, observational study was to delineate the sex differences in platelet function using TEG\u2010PM in patients with PAD on aspirin post\u2010revascularization for PAD. All patients with PAD undergoing revascularization on aspirin monotherapy were prospectively enrolled between December 2020 and September 2023. The cohort was divided by sex, demographics, medications, procedure type, and outcomes were documented. Serial perioperative TEG\u2010PM assays (1, 3, and 6\u2009months) were performed up to 6\u2009months postoperatively and platelet function was evaluated in both groups. Statistical analysis between women and men was performed to identify sex\u2010specific differences in platelet function. Over the study period, a total of 303 patients were enrolled. Of this cohort, 149 patients met the study criteria and 266 samples were analyzed; 52 (34.89%) were women and 97 (65.11%) were men. In the platelet mapping assay, women showed significantly greater MA<jats:sub>ActF<\/jats:sub> and MA<jats:sub>AA<\/jats:sub>, than men (16.66 vs. 14.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.03 and 37.26 vs. 32.38, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01, respectively) indicating stronger thrombotic propensity. Additionally, platelet inhibition was significantly lower in women compared to men (52.95% vs. 61.65%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In clinical outcomes reported as thrombotic events, women showed significantly higher occlusion in the area of intervention than men (4 vs. 1, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). There is a growing awareness of the variations in the natural course, underlying mechanisms, and resulting outcomes of cardiovascular conditions, including PAD, in relation to sex. In this study, women did not achieve the same levels of platelet inhibition and displayed a procoagulant tendency in comparison to men when administered aspirin. Overall, aspirin monotherapy may be potentially sufficient for men, but women may require increased doses and\/or additional antiplatelet medications to achieve an equivalent therapeutic effect.<\/jats:p>","DOI":"10.1002\/ajh.27258","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T06:09:37Z","timestamp":1708754977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The impact of sex on platelet responses to aspirin in patients with peripheral artery disease"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-7258","authenticated-orcid":false,"given":"Sasha P.","family":"Suarez Ferreira","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Morrow","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6416-6846","authenticated-orcid":false,"given":"Ivy","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanah","family":"Hagos","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Zacharias","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Machlus","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children's Hospital and Department of Surgery Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Dua","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"E96","article-title":"Peripheral artery disease in women","volume":"2","author":"Su\u00e1rez Ferreira SP","year":"2022","journal-title":"J Crit Limb Ischem"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.11.063"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320702"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2022.08.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3175-1_49"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23599"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28308-1_17"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348221087905"},{"key":"e_1_2_9_11_1","unstructured":"MajumdarM DuaA.Platelet mapping highlights our burgeoning understanding of sex dimorphism in vascular disease\u2014and all that we have yet to learn.Vascular Disease Management; 2022."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027790"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.08.015"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T17:32:32Z","timestamp":1744565552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":12,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ajh.27258"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27258","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2023-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}