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Conversely, its prognostic value in the newly defined disease entity, myelodysplastic neoplasm (MDS)\/AML is unknown. To assess the relationship between disease type, pre\u2010HCT MRD, and post\u2010HCT outcomes, we retrospectively analyzed 1265 adults with MDS\/AML (<jats:italic>n<\/jats:italic>\u2009=\u2009151) or AML (<jats:italic>n<\/jats:italic>\u2009=\u20091114) who received a first allograft in first or second morphologic remission at a single institution between April 2006 and March 2023. At 3\u2009years, relapse rates (29% for MDS\/AML vs. 29% for AML, <jats:italic>p<\/jats:italic>\u2009=\u2009.98), relapse\u2010free survival (RFS; 50% vs. 55%, <jats:italic>p<\/jats:italic>\u2009=\u2009.22), overall survival (OS; 52% vs. 60%, <jats:italic>p<\/jats:italic>\u2009=\u2009.073), and non\u2010relapse mortality (22% vs. 16%, <jats:italic>p<\/jats:italic>\u2009=\u2009.14) were not statistically significantly different. However, a significant interaction was found between pre\u2010HCT MFC MRD and disease type (MDS\/AML vs. AML) for relapse (<jats:italic>p<\/jats:italic>\u2009=\u2009.009), RFS (<jats:italic>p<\/jats:italic>\u2009=\u2009.011), and OS (<jats:italic>p<\/jats:italic>\u2009=\u2009.039). The interaction models indicated that the hazard ratios (HRs) for the association between pre\u2010HCT MRD and post\u2010HCT outcomes were lower in patients with MDS\/AML (for relapse: HR\u2009=\u20091.75 [0.97\u20133.15] in MDS\/AML vs. 4.13 [3.31\u20135.16] in AML; for RFS: HR\u2009=\u20091.58 [1.02\u20132.45] vs. 2.98 [2.48\u20133.58]; for OS: HR\u2009=\u20091.50 [0.96\u20132.35] vs. 2.52 [2.09\u20133.06]). On the other hand, residual cytogenetic abnormalities at the time of HCT were equally informative in MDS\/AML as in AML patients. Our data indicate that MFC\u2010based pre\u2010HCT MRD testing, but not testing for residual cytogenetic abnormalities, is less informative for MDS\/AML than AML patients when used for prognostication of post\u2010HCT outcomes.<\/jats:p>","DOI":"10.1002\/ajh.27259","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T12:58:58Z","timestamp":1708520338000},"page":"862-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with <scp>MDS<\/scp>\/<scp>AML<\/scp> or <scp>AML<\/scp>"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-0824","authenticated-orcid":false,"given":"Corentin","family":"Orvain","sequence":"first","affiliation":[{"name":"Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Maladies du Sang CHU d'Angers  Angers France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Grand\u2010Ouest Acute Leukemia (FHU\u2010GOAL)  Angers France"},{"name":"Universit\u00e9 d'Angers, Inserm UMR 1307, CNRS UMR 6075, Nantes Universit\u00e9  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Ali","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Othus","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Rodr\u00edguez\u2010Arbol\u00ed","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS\/CSIC) University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-2159","authenticated-orcid":false,"given":"Filippo","family":"Milano","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin M.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Medicine, Residency Program University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-9739","authenticated-orcid":false,"given":"Brenda M.","family":"Sandmaier","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart L.","family":"Scott","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick R.","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-3341","authenticated-orcid":false,"given":"Roland B.","family":"Walter","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington 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