{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:55Z","timestamp":1791266995740,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombosis represents a frequent and potentially severe complication in individuals diagnosed with multiple myeloma (MM). These events can be driven by both the disease as well as the therapies themselves. Overall, available evidence is inconclusive about the differential thrombogenicity of carfilzomib\/lenalidomide\/dexamethasone (KRd) and bortezomib\/lenalidomide\/dexamethasone (VRd). This meta\u2010analysis compares the risk for venous thromboembolism (VTE; including deep venous thrombosis and pulmonary embolism) and arterial thromboembolism (ATE; including myocardial infarction and ischemic stroke) with KRd versus VRd as primary therapy for newly diagnosed MM (NDMM). Out of 510 studies identified after deduplication, one randomized controlled trial and five retrospective cohort studies were included. We analyzed 2304 patients (VRd: 1380; KRd: 924) for VTE events and 2179 patients (VRd: 1316; KRd: 863) for ATE events. Lower rates of VTE were observed in the VRd group when compared with the KRd group (6.16% vs. 8.87%; odds ratio [OR], 0.53; 95% confidence interval [CI], 0.32\u20130.88; <jats:italic>p<\/jats:italic>\u2009=\u2009.01). Both treatment groups exhibited minimal ATE incidence, with no significant difference between them (0.91% vs. 1.16%; OR, 1.01; 95% CI, 0.24\u20134.20; <jats:italic>p<\/jats:italic>\u2009=\u2009.99). In view of potential biases from retrospective studies, heterogeneity of baseline population characteristics, and limited access to patient\u2010level data (e.g., VTE risk stratification and type of thromboprophylaxis regimen used) inherent to this meta\u2010analysis, additional research is warranted to further validate our findings and refine strategies for thrombosis prevention in MM.<\/jats:p>","DOI":"10.1002\/ajh.27288","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:28:42Z","timestamp":1710570522000},"page":"1056-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Thromboembolic risk of carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for newly diagnosed multiple myeloma: A comparative systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-4498","authenticated-orcid":false,"given":"Bruno Almeida","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Sinai Morningside and West Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Medicine Memorial Sloan Kettering Cancer  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-6694","authenticated-orcid":false,"given":"Thomaz Alexandre","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7462-8470","authenticated-orcid":false,"given":"Sara Diaz","family":"Saravia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai Morningside and West Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-3866","authenticated-orcid":false,"given":"Nicole","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Campina Grande  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-2594","authenticated-orcid":false,"given":"Carlyn Rose","family":"Tan","sequence":"additional","affiliation":[{"name":"Myeloma Service, Department of Medicine Memorial Sloan Kettering Cancer  New York New York USA"},{"name":"Department of Medicine Weill Cornell Medicine  New York New York 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