{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:55:21Z","timestamp":1793433321967,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Restless legs syndrome (RLS) is a neurological disorder that can have a profound effect on sleep and quality of life. Idiopathic RLS is associated with brain iron insufficiency despite normal peripheral iron stores. There is, however, a five\u2010 to six\u2010fold increase in prevalence of RLS in patients with iron deficiency anemia (IDA). Several open\u2010label trials have demonstrated symptomatic improvement in RLS following treatment of IDA using oral or intravenous iron supplementation. To date, there have been no randomized double\u2010blind controlled trials of intravenous iron compared with oral iron for the treatment of RLS patients with IDA. In the current study, oral ferrous sulfate and ferumoxytol were compared for efficacy and speed of response for treatment of RLS occurring in patients with IDA. The planned recruitment for this study was 70 patients with RLS and IDA, to be randomly assigned 1:1 to oral or intravenous iron, using double\u2010blind, double\u2010dummy procedures. At Week 6, the primary outcomes of Clinical Global Impression\u2014Improvement score and change from baseline in the International Restless Legs Syndrome Study Group rating scale score were assessed. Due to challenges, performing the clinical trial during the COVID\u201019 pandemic, final\u2010week data were found missing for 30 patients. As a result, in order to maintain the prespecified statistical analysis, an additional 30 patients were recruited. Both IV and oral iron were associated with a marked improvement in RLS symptoms, with no statistically significant difference between treatment groups. No serious adverse events were observed in either treatment group.<\/jats:p>","DOI":"10.1002\/ajh.27290","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T07:23:53Z","timestamp":1710314633000},"page":"1077-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A randomized double\u2010blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-4078","authenticated-orcid":false,"given":"Vanessa","family":"Short","sequence":"first","affiliation":[{"name":"College of Nursing Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-7967","authenticated-orcid":false,"given":"Christopher J.","family":"Earley","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huzefa","family":"Bahrain","sequence":"additional","affiliation":[{"name":"Auerbach Hematology and Oncology  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Rineer","sequence":"additional","affiliation":[{"name":"Auerbach Hematology and Oncology  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiumarce","family":"Kashi","sequence":"additional","affiliation":[{"name":"Baltimore Sleep and Wellness Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Gerb","sequence":"additional","affiliation":[{"name":"Auerbach Hematology and Oncology  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-8647","authenticated-orcid":false,"given":"Michael","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Auerbach Hematology and Oncology  Baltimore Maryland USA"},{"name":"Department of Medicine Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp021288"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.05.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.11.1126"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.11.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.06.009"},{"key":"e_1_2_9_7_1","unstructured":"AuerbachM DeLougheryTG.Treatment of Iron Deficiency Anemia in Adults.2023https:\/\/www.uptodate.com\/contents\/treatment-of-iron-deficiency-anemia-in-adults#H30"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21607"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.11.1286"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23397"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/21.4.381"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1953.tb07042.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.08.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.10.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00006-6"},{"key":"e_1_2_9_16_1","unstructured":"AMAG Pharmaceuticals I.Feraheme\u00ae (ferumoxytol injection) for Intravenous Use. 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