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We performed a systematic review and meta\u2010analysis of trials investigating organ function before and after HSCT in patients with SCD. We searched MEDLINE\/PubMed and EMBASE up to September 21, 2023. Continuous data were expressed as standardized mean difference (SMD) and pooled in a weighted inverse\u2010variance random\u2010effects model; binomial data were expressed as risk ratio (RR) using the Mantel\u2013Haenszel random\u2010effects meta\u2010analyses. Of 823 screened studies, 34 were included in this review. Of these, 17 (774 patients, 23.6% adults, 86.3% HLA\u2010identical sibling donor, 56.7% myeloablative conditioning regimen) were included in the meta\u2010analyses. Pulmonary function remained stable. Mean tricuspid regurgitant jet velocity decreased but did not reach statistical significance. In children, estimated glomerular filtration rate decreased (SMD \u22120.80, <jats:italic>p<\/jats:italic>\u2009=\u2009.01), and the presence of proteinuria increased (RR 2.00, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.01), while splenic uptake and phagocytic function improved (RR 0.31, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.01; RR 0.23, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.01). Cerebral blood flow improved (SMD \u22121.39, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.01), and a low incidence of stroke after transplantation in high\u2010risk patients was found. Retinopathy and avascular osteonecrosis were investigated in only one study, showing no significant changes. While HSCT can improve some SCD\u2010related organ dysfunctions, transplantation\u2010related toxicity may have an adverse effect on others. Future research should focus on identifying individuals with SCD who might benefit most from HSCT and which forms of organ damage are more likely to exacerbate post\u2010transplantation.<\/jats:p>","DOI":"10.1002\/ajh.27297","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:34:47Z","timestamp":1711114487000},"page":"1129-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of allogeneic hematopoietic stem cell transplantation on sickle cell disease\u2010related organ complications: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-1907","authenticated-orcid":false,"given":"Elisabeth","family":"Dovern","sequence":"first","affiliation":[{"name":"Department of Hematology, Amsterdam University Medical Centers location University of Amsterdam  Amsterdam The 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