{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:40:28Z","timestamp":1772649628000,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the phase 2 GRIFFIN trial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT02874742), daratumumab added to lenalidomide, bortezomib, and dexamethasone (D\u2010RVd) improved depth of response and progression\u2010free survival (PFS) versus lenalidomide, bortezomib, and dexamethasone (RVd) alone in transplant\u2010eligible (TE) patients with newly diagnosed multiple myeloma (NDMM). Here, we present patient\u2010reported outcomes (PROs) collected using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30\u2010item (QLQ\u2010C30), EORTC Quality of Life Questionnaire Multiple Myeloma Module 20\u2010item (QLQ\u2010MY20), and EuroQol 5\u2010Dimension 5\u2010Level (EQ\u20105D\u20105L) tools on day 1 of cycles 1, 2, and 3; on day 21 of cycle 4 (end of induction therapy); on day 1 of cycle 5; on day 21 of cycle 6 (end of posttransplant consolidation therapy); and at months 6, 12, 18, and 24 of maintenance therapy. Meaningful improvements from baseline were seen in most of the PRO scales with both treatments after consolidation and were sustained for at least 2\u2009years of maintenance treatment. Large reductions from baseline (~20 points) were especially observed in pain symptoms for both treatment groups, although these were numerically higher for patients receiving D\u2010RVd during the majority of the time points. In addition, improvements in key scales, such as global health status, fatigue symptoms, and physical functioning, were also seen with both D\u2010RVd and RVd. These improvements in health\u2010related quality of life contribute to the totality of evidence supporting the improvement in clinical outcomes such as response rates and PFS with D\u2010RVd in induction, consolidation, and maintenance therapy in TE patients with NDMM.<\/jats:p>","DOI":"10.1002\/ajh.27326","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T05:13:50Z","timestamp":1713244430000},"page":"1257-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Health\u2010related quality of life in transplant\u2010eligible patients with newly diagnosed multiple myeloma treated with daratumumab, lenalidomide, bortezomib, and dexamethasone: Patient\u2010reported outcomes from <scp>GRIFFIN<\/scp>"],"prefix":"10.1002","volume":"99","author":[{"given":"Rebecca","family":"Silbermann","sequence":"first","affiliation":[{"name":"Division of Hematology\/Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Laubach","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber\/Partners Cancer Care  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-6429","authenticated-orcid":false,"given":"Jonathan L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Mematology and Medical Oncology Winship Cancer Institute, Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Sborov","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies Huntsman Cancer Institute, University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-3698","authenticated-orcid":false,"given":"Brandi","family":"Reeves","sequence":"additional","affiliation":[{"name":"Division of Hematology University of North Carolina\u2013Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Mount Sinai School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajai","family":"Chari","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Mount Sinai School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-2469","authenticated-orcid":false,"given":"Luciano J.","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Larry D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Simmons Comprehensive Cancer Center, UT Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitya","family":"Nathwani","sequence":"additional","affiliation":[{"name":"Division of Myeloma Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Bumma","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Holstein","sequence":"additional","affiliation":[{"name":"Division of Oncology and Hematology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Costello","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation Moores Cancer Center, University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Jakubowiak","sequence":"additional","affiliation":[{"name":"Medicine\u2010 Hematology and Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H.","family":"Shain","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-8415","authenticated-orcid":false,"given":"Katharine S.","family":"Gries","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development  Raritan New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Pei","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Titusville New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelore","family":"Cortoos","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Horsham Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmila","family":"Patel","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Horsham Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Lin","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Horsham Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1661-718X","authenticated-orcid":false,"given":"Peter M.","family":"Voorhees","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology and Blood Disorders Levine Cancer Institute, Atrium Health\/Wake Forest University School of Medicine  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad Z.","family":"Usmani","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-8865","authenticated-orcid":false,"given":"Paul G.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber\/Partners Cancer Care  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000528"},{"key":"e_1_2_9_4_1","unstructured":"DARZALEX\u00ae.Prescribing information. Janssen Biotech Inc.2015.Accessed February 20 2023.https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/DARZALEX-pi.pdf"},{"key":"e_1_2_9_5_1","unstructured":"European Medicines Agency.DARZALEX 20 mg\/mL concentrate for solution for infusion. Summary of product characteristics.2016.Accessed February 20 2023.https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/darzalex-epar-product-information_en.pdf"},{"key":"e_1_2_9_6_1","unstructured":"DARZALEX FASPRO\u00ae.Prescribing information. Janssen Biotech Inc.2021.Accessed February 2 2023.https:\/\/www.janssenlabels.com\/package\u2010insert\/product\u2010monograph\/prescribing\u2010information\/DARZALEX+Faspro\u2010pi.pdf"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005288"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00217-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312054"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00611-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12790"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_200383"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1875762"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw317"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.352889.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.04.022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01665.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13316"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-70"},{"key":"e_1_2_9_21_1","volume-title":"EORTC QLQ\u2010C30 Scoring Manual","author":"Fayers P","year":"2001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04356-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.10.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3181f9904d"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-019-02392-6"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"S26","article-title":"Disparities in multiple myeloma among African Americans","volume":"115","author":"Bhutani M","year":"2023","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1719091"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204925"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01370"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30356-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00543-y"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0141-0"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:51:36Z","timestamp":1718131896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ajh.27326"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27326","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"2023-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}