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The generalizability of pan\u2010cancer models to lymphomas is limited. Currently, there are no reliable risk prediction models for thrombosis in patients with lymphoma. Our objective was to create a risk assessment model (RAM) specifically for lymphomas. We performed a retrospective cohort study to develop Fine and Gray sub\u2010distribution hazard model for VTE and pulmonary embolism (PE)\/ lower extremity deep vein thrombosis (LE\u2010DVT) respectively in adult lymphoma patients from the Veterans Affairs national healthcare system (VA). External validations were performed at the Harris Health System (HHS) and the MD Anderson Cancer Center (MDACC). Time\u2010dependent c\u2010statistic and calibration curves were used to assess discrimination and fit. There were 10,313 (VA), 854 (HHS), and 1858 (MDACC) patients in the derivation and validation cohorts with diverse baseline. At 6\u2009months, the VTE incidence was 5.8% (VA), 8.2% (HHS), and 8.8% (MDACC), respectively. The corresponding estimates for PE\/LE\u2010DVT were 3.9% (VA), 4.5% (HHS), and 3.7% (MDACC), respectively. The variables in the final RAM included lymphoma histology, body mass index, therapy type, recent hospitalization, history of VTE, history of paralysis\/immobilization, and time to treatment initiation. The RAM had c\u2010statistics of 0.68 in the derivation and 0.69 and 0.72 in the two external validation cohorts. The two models achieved a clear differentiation in risk stratification in each cohort. Our findings suggest that easy\u2010to\u2010implement, clinical\u2010based model could be used to predict personalized VTE risk for lymphoma patients.<\/jats:p>","DOI":"10.1002\/ajh.27335","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:40:57Z","timestamp":1713919257000},"page":"1230-1239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Thrombosis risk prediction in lymphoma patients: A m\n                    <scp>ulti\u2010institutional<\/scp>\n                    , retrospective model development and validation study"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-8892","authenticated-orcid":false,"given":"Shengling","family":"Ma","sequence":"first","affiliation":[{"name":"Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas 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