{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:34:51Z","timestamp":1782632091281,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the context of T\u2010cell replete haploidentical stem cell transplantation (Haplo\u2010SCT) using post\u2010transplantation cyclophosphamide (PT\u2010Cy), it is still unknown whether peripheral blood (PB) or bone marrow (BM) is the best graft source. While PB is associated with a higher incidence of graft\u2010versus\u2010host disease (GVHD), it may induce a stronger graft\u2010versus\u2010leukemia effect compared to BM, notably in acute myeloid leukemia (AML). From the EBMT registry database, we compared T\u2010cell replete PB (<jats:italic>n<\/jats:italic>\u2009=\u2009595) versus BM (<jats:italic>n<\/jats:italic>\u2009=\u2009209) grafts in a large cohort of 804 patients over the age of 60\u2009years who underwent Haplo\u2010SCT with PT\u2010Cy for an AML in first or second complete remission. The risk of acute GVHD was significantly higher in the PB group (Grade II\u2010IV: HR\u2009=\u20091.67, 95% CI [1.10\u20132.54], <jats:italic>p<\/jats:italic>\u2009=\u20090.01; Grade III\u2010IV: HR\u2009=\u20092.29, 95% CI [1.16\u20134.54], <jats:italic>p<\/jats:italic>\u2009=\u20090.02). No significant difference was observed in chronic GVHD or non\u2010relapse mortality. In the PB group, the risk of relapse was significantly lower in the PB group (HR\u2009=\u20090.65, 95% CI [0.45\u20130.94], <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and leukemia\u2010free survival was significantly better (HR\u2009=\u20090.76, 95% CI [0.59\u20130.99], <jats:italic>p<\/jats:italic>\u2009=\u20090.04), with a trend toward better overall survival (HR\u2009=\u20090.78, 95% CI [0.60\u20131.01], <jats:italic>p<\/jats:italic>\u2009=\u20090.06). We conclude that in the specific context of Haplo\u2010SCT with PT\u2010Cy, PB grafts represent a valid option to decrease the risk of relapse and improve outcome of older AML patients who usually do not benefit from conditioning intensification.<\/jats:p>","DOI":"10.1002\/ajh.27343","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T07:03:48Z","timestamp":1716447828000},"page":"1250-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peripheral blood stem cell versus bone marrow graft for patients \u226560\u2009years undergoing reduced intensity conditioning haploidentical transplantation for acute myeloid leukemia in complete remission: An analysis of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-8310","authenticated-orcid":false,"given":"Raynier","family":"Devillier","sequence":"first","affiliation":[{"name":"Transplantation and Cell Therapy Program, Institut Paoli Calmettes\u2013Marseille, Centre de Recherche en Canc\u00e9rologie de Marseille Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques\u2010Emmanuel","family":"Galimard","sequence":"additional","affiliation":[{"name":"EBMT Statistical Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplantation and Cell Therapy Program, Institut Paoli Calmettes\u2013Marseille, Centre de Recherche en Canc\u00e9rologie de Marseille Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Raiola","sequence":"additional","affiliation":[{"name":"Ematologia e Terapie Cellulari, IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Transplantation Unit Department of Oncology and Haematology IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Pastano","sequence":"additional","affiliation":[{"name":"Onco\u2010Haematology Division, European Institute of Oncology IRCCS IEO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-4753","authenticated-orcid":false,"given":"R\u00e9gis Peffault","family":"de Latour","sequence":"additional","affiliation":[{"name":"Department of Hematology \u2013 BMT, Hopital St. Louis Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"S.S. 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