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Ponatinib was approved for T315I\u2010mutated chronic myeloid leukemia (CML), CML resistant\/intolerant to \u22652 prior TKIs, advanced phase CML and Ph\u2010positive acute lymphoblastic leukemia (ALL) where no other TKIs are indicated, and T315I\u2010mutated CML and Ph\u2010positive ALL. The response\u2010based dosing of ponatinib in chronic phase CML (CP\u2010CML) improved treatment tolerance and reduced the risk of toxicities, including cardiovascular risks. Ponatinib\u2010based therapy also resulted in significantly better outcomes in frontline Ph\u2010positive ALL compared with prior TKIs and is becoming a new standard of care in this setting. As the clinical development of third\u2010generation TKIs and their rational combinations progresses, we envision further transformative changes in the treatment of CML and Ph\u2010positive ALL.<\/jats:p>","DOI":"10.1002\/ajh.27355","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:03:16Z","timestamp":1715328196000},"page":"1576-1585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Ponatinib\u2010review of historical development, current status, and future research"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop M.","family":"Kantarjian","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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