{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:09:19Z","timestamp":1790392159983,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Venetoclax\u2010azacitidine is the standard of treatment for unfit acute myeloid leukemia patients. In the VIALE\u2010A study, treatment was given until progression but there are no data on its optimal duration for responding patients who do not tolerate indefinite therapy. We retrospectively analyzed the outcome of patients who discontinued venetoclax or venetoclax\u2010azacitidine due to poor tolerance. Sixty\u2010two newly diagnosed (ND) AML patients and 22 patients with morphological relapse or refractory AML were included. In the ND cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200962), 28 patients stopped venetoclax and azacitidine and 34 patients continued azacitidine monotherapy. With a median follow\u2010up of 23\u2009months (IQR, 20\u201332), median overall survival and treatment\u2010free survival were 44 (IQR, 16\u2010NR) and 16 (IQR, 8\u201327) months, respectively. Patients who stopped both treatments and those who continued azacitidine monotherapy had the same outcomes. Negative minimal residual disease was associated with a 2\u2010year treatment\u2010free survival of 80%. In the RR cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922), median overall survival and treatment\u2010free survival were 19 (IQR, 17\u201331) and 10 (IQR, 5\u2010NR) months, respectively. Prior number of venetoclax\u2010azacitidine cycles and\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations were associated with increased overall survival. The only factor significantly impacting treatment\u2010free survival was the number of prior cycles. This study suggests that patients who discontinued treatment in remission have favorable outcomes supporting the rationale for prospective controlled trials.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27417","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:15:01Z","timestamp":1718864101000},"page":"1870-1876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Outcomes of acute myeloid leukemia patients who responded to venetoclax and azacitidine and stopped treatment"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-1255","authenticated-orcid":false,"given":"Sylvain","family":"Garciaz","sequence":"first","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie, Institut Paoli\u2010Calmettes Universit\u00e9 d'Aix\u2010Marseille, INSERM U1068, CNRS  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Yves","family":"Dumas","sequence":"additional","affiliation":[{"name":"CHU Bordeaux Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire  Bordeaux France"},{"name":"BRIC (BoRdeaux Institute of onCology), UMR1312, INSERM Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-2781","authenticated-orcid":false,"given":"Sarah","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse\u2010Oncopole Universit\u00e9 de Toulouse, UPS, Service d'h\u00e9matologie  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-8233","authenticated-orcid":false,"given":"David A.","family":"Sallman","sequence":"additional","affiliation":[{"name":"Malignant Hematology Department H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Decroocq","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie H\u00f4pital Cochin, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-4830","authenticated-orcid":false,"given":"Amine","family":"Belhabri","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie, Centre L\u00e9on B\u00e9rard Centre de Recherche en Cancerologie de Lyon (CRCL) UMR INSERM 1052, CNRS 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-0824","authenticated-orcid":false,"given":"Corentin","family":"Orvain","sequence":"additional","affiliation":[{"name":"Maladies du Sang CHU d'Angers  Angers France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Grand\u2010Ouest Acute Leukemia, FHU\u2010GOAL  Angers France"},{"name":"Universit\u00e9 d'Angers, Inserm UMR 1307, CNRS UMR 6075, Nantes Universit\u00e9, CRCI2NA  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspar","family":"Aspas Requena","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine","family":"Simand","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie ICANS (Institut for Cancer Strasbourg\u2010Europe)  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Laribi","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CH Le Mans  Le Mans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CHU de Grenoble  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Santagostino","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CH Troyes  Troyes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Himberlin","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-6686","authenticated-orcid":false,"given":"Pierre","family":"Peterlin","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'h\u00e9matologie CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2320-6729","authenticated-orcid":false,"given":"Sarah","family":"Bonnet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'H\u00e9matologie Clinique CHRU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-1961","authenticated-orcid":false,"given":"Onyee","family":"Chan","sequence":"additional","affiliation":[{"name":"Malignant Hematology Department H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-7310","authenticated-orcid":false,"given":"Jeffrey","family":"Lancet","sequence":"additional","affiliation":[{"name":"Malignant Hematology Department H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Komrokji","sequence":"additional","affiliation":[{"name":"Malignant Hematology Department H. 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