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While tailored and biomarker\u2010targeted therapy remains the direct goal for patient\u2010centric management, existing therapies in MM remain largely uniform. Translocation t(14;16) is a rare primary genetic event found in less than 5% of patients with newly diagnosed MM. Here, we present an overview of the biology of t(14;16), epidemiology, clinical presentation, prognostic impact, and discuss the future clinical and therapeutic strategies for targeting this rare yet high\u2010risk group in MM to optimize patient outcomes.<\/jats:p>","DOI":"10.1002\/ajh.27419","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:45:23Z","timestamp":1718351123000},"page":"1979-1987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Still high risk? 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