{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:34Z","timestamp":1786976854029,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The best donor option for acute myeloid leukemia (AML) patients lacking an HLA\u2010matched donor has remained intensively debated. We herein report the results of a large retrospective registry study comparing hematopoietic cell transplantation (HCT) outcomes between double\u2010unit umbilical cord blood transplantation (dCBT,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009209) versus 9\/10 HLA\u2010matched unrelated donor (UD) with posttransplant cyclophosphamide (PTCy)\u2010based graft\u2010versus\u2010host disease (GVHD) prophylaxis (UD 9\/10,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009270) in patients with AML in first complete remission (CR1). Inclusion criteria consisted of adult patient, AML in CR1 at transplantation, either peripheral blood stem cells (PBSC) from UD 9\/10 with PTCy as GVHD prophylaxis or dCBT without PTCy, transplantation between 2013 and 2021, and no in vivo T\u2010cell depletion. The 180\u2010day cumulative incidence of grade II\u2010IV acute GVHD was 29% in UD 9\/10 versus 44% in dCBT recipients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001). After adjustment for covariates, dCBT recipients had a higher non\u2010relapse mortality (HR\u2009=\u20092.35, 95% CI: 1.23\u20134.48;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.01), comparable relapse incidence (HR\u2009=\u20091.12, 95% CI: 0.67\u20131.86;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.66), lower leukemia\u2010free survival (HR\u2009=\u20091.5, 95% CI: 1.01\u20132.23;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.047), and lower overall survival (HR\u2009=\u20091.66, 95% CI: 1.08\u20132.55;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02) compared with patients receiving UD 9\/10 HCT. In summary, our results suggest that transplantation outcomes are better with UD 9\/10 with PTCy\u2010based GVHD prophylaxis than with dCBT for AML patients in CR1. These data might support the use of UD 9\/10 with PTCy\u2010based GVHD prophylaxis over dCBT in AML patients lacking an HLA\u2010matched donor.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27466","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T05:03:20Z","timestamp":1725080600000},"page":"2296-2305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Higher survival following transplantation with a mismatched unrelated donor with posttransplant cyclophosphamide\u2010based graft\u2010versus\u2010host disease prophylaxis than with double unit umbilical cord blood in patients with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-3812","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Baron","sequence":"first","affiliation":[{"name":"Laboratory of Hematology, GIGA\u2010I3 University of Liege and CHU of Li\u00e8ge  Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Unit  Paris France"},{"name":"Clinical Hematology and Cellular Therapy Department Saint Antoine Hospital  Paris France"},{"name":"INSERM UMRs 938  Paris France"},{"name":"Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurjen","family":"Versluis","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam  Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vydra","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"von dem Borne","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6439-0795","authenticated-orcid":false,"given":"Emma","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de transplantation et d'immunoth\u00e9rapie cellulaire, d\u00e9partement d'h\u00e9matologie, Institut Paoli Calmettes, Laboratoire management sport cancer, Aix Marseille universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Protheroe","sequence":"additional","affiliation":[{"name":"University Hospitals Bristol and Weston NHS Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-4136","authenticated-orcid":false,"given":"Alexander","family":"Kulagin","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute Pavlov University  Saint Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Eric","family":"Bulabois","sequence":"additional","affiliation":[{"name":"CHU Grenoble Alpes \u2013 Universit\u00e9 Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hospital Clinic  Barcelona 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