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Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte\u2010rich HL are subgroups of classical HL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk Stratification<\/jats:title>\n                    <jats:p>An accurate assessment of the stage of disease in patients with HL is critical for the selection of the appropriate therapy. Prognostic models that identify patients at low or high risk for recurrence, as well as the response to therapy as determined by positron emission tomography (PET) scan, are used to optimize therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk\u2010Adapted Therapy<\/jats:title>\n                    <jats:p>Initial therapy for HL patients is based on the histology of the disease, the anatomical stage and the presence of poor prognostic features. Patients with early\u2010stage disease are typically treated with combined modality strategies utilizing abbreviated courses of combination chemotherapy followed by involved\u2010field radiation therapy, whereas those with advanced stage disease receive a longer course of chemotherapy often without radiation therapy. However, newer agents including brentuximab vedotin and anti\u2010PD\u20101 antibodies are now standardly incorporated into frontline therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management of Relapsed\/Refractory Disease<\/jats:title>\n                    <jats:p>High\u2010dose chemotherapy (HDCT) followed by an autologous stem cell transplant (ASCT) is the standard of care for most patients who relapse following initial therapy. For patients who fail HDCT with ASCT, brentuximab vedotin, PD\u20101 blockade, non\u2010myeloablative allogeneic transplant or participation in a clinical trial should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.27470","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T06:27:39Z","timestamp":1725604059000},"page":"2367-2378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Hodgkin lymphoma: 2025 update on diagnosis, risk\u2010stratification, and management"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-6758","authenticated-orcid":false,"given":"Stephen M.","family":"Ansell","sequence":"first","affiliation":[{"name":"Dorotha W. and Grant L. 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