{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:04:51Z","timestamp":1766387091262,"version":"3.48.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute myeloid leukemia (AML) with translocation t(8;16)(p11;p13) represents a rare entity that has been categorized as a disease\u2010defining recurring cytogenetic abnormality with adverse risk in the 2022 European LeukemiaNet classification. This rating was mainly based on a retrospective analysis comprising patients from several large clinical trials, which, however, included only 21 patients treated with allogeneic stem cell transplantation (alloSCT). Therefore, the European Society for Blood and Marrow Transplantation performed a registry study on a larger cohort to evaluate the role of alloSCT in t(8;16) AML. Sixty transplant recipients with t(8;16) AML were identified. Two\u2010year overall and leukemia\u2010free survival (OS\/LFS) was 43\/39%. Patients transplanted in first complete remission (CR1,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200944) achieved a 2\u2010year OS\/LFS of 48%\/48%. Following alloSCT in CR1, the multivariable analysis identified a complex karyotype (CK) as a major risk factor for relapse (HR 4.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.016), lower LFS (HR 3.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.01), and lower OS (HR 3.08,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.017). Two\u2010year OS\/LFS of patients with CK was 19%\/19%, in contrast to 67%\/67% in patients with t(8;16) outside a CK. Other factors for inferior outcomes were older age and secondary AML. In summary, alloSCT could mitigate the adverse risk of patients with t(8;16) AML not harboring a CK, particularly when performed in CR1.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27496","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T23:39:36Z","timestamp":1731973176000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of allogeneic stem cell transplantation in acute myeloid leukemia with translocation t(8;16)(p11;p13)"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-8685","authenticated-orcid":false,"given":"Ann\u2010Kristin","family":"Schm\u00e4lter","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Augsburg University Hospital and Medical Faculty Comprehensive Cancer Center Augsburg  Augsburg Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Office  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurjen","family":"Versluis","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Center Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pilar","family":"Gallego Hernanz","sequence":"additional","affiliation":[{"name":"Hematology Department CHU de Poitiers  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"von dem Borne","sequence":"additional","affiliation":[{"name":"Leiden University Hospital BMT Centre Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Saint\u2010Louis Hospital, BMT Unit  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-5581","authenticated-orcid":false,"given":"Patrice","family":"Chevallier","sequence":"additional","affiliation":[{"name":"CHU Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"CHU Bordeaux H\u00f4pital Haut\u2010Leveque  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Clinic for Hematology, Oncology, Immunology, and Carreras Leukemia Center Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Baron","sequence":"additional","affiliation":[{"name":"CHU and University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-4997","authenticated-orcid":false,"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Program, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-131X","authenticated-orcid":false,"given":"Gesine","family":"Bug","sequence":"additional","affiliation":[{"name":"Department for Hematology and Oncology University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center Tel Aviv University  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Augsburg University Hospital and Medical Faculty Comprehensive Cancer Center Augsburg  Augsburg Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Clinic Barcelona, IDIBAPS  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Office  Paris France"},{"name":"Department of Haematology Saint Antoine Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele, Hematology and BMT University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.128"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-301713"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.388"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4601"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.278"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17336"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03637-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2014.10.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.08.025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab178"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.305"},{"key":"e_1_2_11_15_1","unstructured":"EBMT.EBMT Manual 2019.2019Accessed 17 July 2024.https:\/\/www.ebmt.org\/sites\/default\/files\/2019-05\/MEDABFormsManual_0.pdf"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.7605"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31311"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0296-3"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:00:37Z","timestamp":1766386837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ajh.27496"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27496","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"type":"print","value":"0361-8609"},{"type":"electronic","value":"1096-8652"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}