{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:54:19Z","timestamp":1787957659751,"version":"build-2784847793"},"reference-count":196,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Beta (\u03b2)\u2010thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable state, which can significantly influence organ complication and disease severity. While red blood cells (RBCs) and erythroblasts continue to play a central role in the pathogenesis of thrombosis in \u03b2\u2010thalassemia and SCD, additional factors such as free heme, inflammatory vasculopathy, splenectomy, among other factors further contribute to the complexity of thrombotic risk. Thus, understanding the role of the numerous factors driving this hypercoagulable state will enable healthcare practitioners to enhance preventive and treatment strategies and develop novel therapies for the future. We herein describe the pathogenesis of thrombosis in patients with \u03b2\u2010thalassemia and SCD. We also identify common mechanisms underlying the procoagulant profile of hemoglobinopathies translating into thrombotic events. Finally, we review the currently available prevention and clinical management of thrombosis in these patient populations.<\/jats:p>","DOI":"10.1002\/ajh.27500","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:35:27Z","timestamp":1728887727000},"page":"103-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-5094","authenticated-orcid":false,"given":"Rayan","family":"Bou\u2010Fakhredin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community University of Milan  Milan Italy"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico SC Medicina ad Indirizzo Metabolico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-6864","authenticated-orcid":false,"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico SC Medicina ad Indirizzo Metabolico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2238","authenticated-orcid":false,"given":"Ali T.","family":"Taher","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-777X","authenticated-orcid":false,"given":"Lucia","family":"De Franceschi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona, and Azienda Ospedaliera Universitaria Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2023.102758"},{"issue":"3","key":"e_1_2_12_3_1","article-title":"EHA research roadmap on hemoglobinopathies and thalassemia: an update","volume":"3","author":"Iolascon A","year":"2019","journal-title":"Hema"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010117"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-818187"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2022.12.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001384"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155279"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.239350"},{"issue":"8","key":"e_1_2_12_10_1","article-title":"2021 Thalassaemia international federation guidelines for the management of transfusion\u2010dependent thalassemia","volume":"6","author":"Farmakis D","year":"2022","journal-title":"Hema"},{"key":"e_1_2_12_11_1","volume-title":"Guidelines for the Management of Non\u2010Transfusion\u2010Dependent \u03b2\u2010Thalassaemia","author":"Taher A","year":"2023"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00536-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2021838"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273087"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"147","article-title":"The role of phosphatidylserine in recognition and removal of erythrocytes","volume":"50","author":"Kuypers FA","year":"2004","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010Grand)"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02482.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050829"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810109168817"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.003"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.130179"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050967"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.561917"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020296"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2024.01.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-189009"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2022.100102"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17361"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31386-6"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10101"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2023.08.009"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020004853"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2013.11.011"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.640"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2020.66.5.5"},{"issue":"1","key":"e_1_2_12_37_1","article-title":"Coagulopathy in beta\u2010thalassemia: current understanding and future perspectives","volume":"1","author":"Cappellini MD","year":"2009","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02376.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20945"},{"issue":"9","key":"e_1_2_12_40_1","article-title":"MTHFR C677T, prothrombin G20210A, and factor V Leiden (G1691A) polymorphism and Beta\u2010thalassemia risk: a meta\u2010analysis","volume":"12","author":"Nigam N","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.36"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613588"},{"issue":"10","key":"e_1_2_12_43_1","first-page":"1112","article-title":"Thrombophilia in thalassemia major patients: analysis of genetic predisposing factors","volume":"86","author":"Iolascon A","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.04.001"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.016"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13717"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000193"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017074"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000755"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20653"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/918916"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12460"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280233"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001064"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-722298"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06036-7"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61971-7"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026373"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203430"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22156-5"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04422.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-343061"},{"issue":"4","key":"e_1_2_12_63_1","first-page":"556","article-title":"Increased circulating platelet aggregates in thalassaemia","volume":"12","author":"Winichagoon P","year":"1981","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"1","key":"e_1_2_12_64_1","first-page":"4774","article-title":"Platelet aggregation dysfunction in sickle cell disease","volume":"130","author":"Brzoska T","year":"2017","journal-title":"Blood"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.239343"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.8.1749.1749"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-03-0157"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1562170"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08087.x"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00627.x"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2019.002"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061697"},{"issue":"5","key":"e_1_2_12_73_1","article-title":"High\u2010mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease","volume":"9","author":"Nolfi\u2010Donegan D","year":"2024","journal-title":"JCI Insight"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0267"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03940.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1259785"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03576-2"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243154"},{"issue":"1","key":"e_1_2_12_79_1","first-page":"19","article-title":"Vascular brain damage in thalassemia syndrome: an emerging challenge","volume":"16","author":"Hashemieh M","year":"2022","journal-title":"Iran J Child Neurol"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2508-7"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.06.010"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03414-y"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.07.013"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03651.x"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0661"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001432"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020683"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-023-01678-7"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-024-3087-2"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014862"},{"key":"e_1_2_12_91_1","volume-title":"Guidelines for the Management of Transfusion Dependent Thalassaemia","author":"Cappellini MD","year":"2021"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2021.100912"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.09.029"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026082"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2017.1374969"},{"issue":"6","key":"e_1_2_12_96_1","first-page":"477","article-title":"Heavy metal! A case of severe iron overload and supraventricular arrhythmias in a thalassemia major patient","volume":"23","author":"Marchini F","year":"2022","journal-title":"G Ital Cardiol (Rome)"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12040491"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910182"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000848928.08455.02"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00208-3"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122724"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103583"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25502"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3094"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01620.x"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-408021"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01192.x"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021015340"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2022.100101"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206498"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-245085"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18743"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-822593"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007802"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211055385"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2011.10.004"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2531-8"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19650"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.12.016"},{"issue":"10","key":"e_1_2_12_120_1","first-page":"1467","article-title":"Sex as an independent risk factor for venous thromboembolism in sickle cell disease: a cross\u2010sectional study","volume":"31","author":"Roe AH","year":"2022","journal-title":"J Womens Health"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27045"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2015.12.003"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179636"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S383472"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120412"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2021.2022778"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.744118"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2023.2282017"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1112865"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-125846"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-190569"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-618561"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094792"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2023.104209"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005565"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134410"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1222OC"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.727"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001142"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00003-0"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005992"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.619411"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.03.072"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011572"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.05.139"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00837-y"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014095"},{"issue":"4","key":"e_1_2_12_148_1","first-page":"234","article-title":"Antiplatelet agents for preventing vaso\u2010occlusive events in people with sickle cell disease: a systematic review","volume":"17","author":"Marti\u2010Carvajal A","year":"2019","journal-title":"Clin Adv Hematol Oncol"},{"issue":"7","key":"e_1_2_12_149_1","article-title":"The role of antiplatelet in the management of sickle cell disease patients","volume":"15","author":"Naramreddy S","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1817736"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007308"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051193"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-079363"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19428"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020728"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.01.028"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024786"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12362"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00272-2018"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04861.x"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01758.x"},{"issue":"2","key":"e_1_2_12_162_1","first-page":"169","article-title":"Enhanced thrombin generation in children with sickle cell disease","volume":"71","author":"Peters M","year":"1994","journal-title":"Thromb Haemost"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1974.00320160129011"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810109168816"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830230403"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb03685.x"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2001.115450"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb02989.x"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11763"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12632"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615948"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00530.x"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199504000-00001"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90915-1"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2020.66.5.5"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165845"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(99)90149-X"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.07.009"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.4103\/joah.joah_31_23"},{"issue":"7","key":"e_1_2_12_180_1","first-page":"611","article-title":"Elevated immunoreactive tumor necrosis factor and interleukin\u20101 in sickle cell disease","volume":"84","author":"Francis RB","year":"1992","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200103"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204390"},{"issue":"3","key":"e_1_2_12_183_1","first-page":"320","article-title":"Plasma protein C levels in children with sickle cell disease","volume":"11","author":"Karayalcin G","year":"1989","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-08-0436"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470409"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00282-996-0279-2"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00282-997-0229-7"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb03033.x"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1502965.x"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029607306397"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.3.421"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199604)51:4<296::AID-AJH8>3.0.CO;2-R"},{"issue":"4","key":"e_1_2_12_193_1","first-page":"323","article-title":"Platelet count and platelet factor 3 (PF\u20103) availability in sickle cell disease","volume":"52","author":"Famodu AA","year":"1995","journal-title":"Br J Biomed Sci"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000220374.00602.a2"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.7.622"},{"issue":"1","key":"e_1_2_12_196_1","first-page":"17","article-title":"Platelet activation during steady state sickle cell disease","volume":"14","author":"Westwick J","year":"1983","journal-title":"J Med"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830440114"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:00:47Z","timestamp":1766386847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":196,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ajh.27500"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27500","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"2024-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}