{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:28:12Z","timestamp":1788964092932,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    According to current recommendations, older AML patients in first complete remission (CR) after induction chemotherapy should receive consolidation with intermediate\u2010dose cytarabine (IDAC). However, no study has demonstrated the superiority of IDAC over other regimen. In this retrospective study, we compared the efficacy of mini\u2010consolidations (idarubicin 8\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    day 1, cytarabine 50\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/12\u2009h, day 1\u20135) and IDAC. Inclusion criteria were newly diagnosed AML, age\u2009&gt;\u200960\u2009years, first CR after induction and at least 1\u2009cycle of consolidation. Of the 796 included patients, 322 patients received mini\u2010consolidations and 474 patients received IDAC. Mini\u2010consolidation patients were older, and more often, they had de novo AML and unfavorable risk. The rate of allogeneic transplantation was higher in the IDAC group. The median number of cycles was higher in the mini\u2010consolidation group (4 vs. 2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). Median relapse\u2010free survival was 18\u2009months with mini\u2010consolidations and 12\u2009months with IDAC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0064). In multivariate analysis, the risk of relapse or death was significantly higher in the IDAC group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.004). Median OS was 36 versus 31\u2009months with mini\u2010consolidations or IDAC, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.46). In multivariate analysis, the consolidation regimen had no significant influence on OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.43). In older AML patients, post\u2010remission therapy with mini\u2010consolidations represents an alternative to IDAC.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27510","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T07:29:42Z","timestamp":1731914982000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mini\u2010consolidations or intermediate\u2010dose cytarabine for the post\u2010remission therapy of AML patients over 60. A retrospective study from the DATAML and SAL registries"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-4525","authenticated-orcid":false,"given":"Christian","family":"R\u00e9cher","sequence":"first","affiliation":[{"name":"Institut Universitaire du Cancer de Toulouse Oncopole, Centre Hospitalier Universitaire de Toulouse Universit\u00e9 Toulouse III Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Yves","family":"Dumas","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1312, Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire Universit\u00e9 de Bordeaux, CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"B\u00e9rard","sequence":"additional","affiliation":[{"name":"Service d'Epid\u00e9miologie, CERPOP, Inserm, Centre Hospitalier Universitaire de Toulouse Universit\u00e9 Toulouse III Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Tavitian","sequence":"additional","affiliation":[{"name":"Institut Universitaire du Cancer de Toulouse Oncopole, Centre Hospitalier Universitaire de Toulouse Universit\u00e9 Toulouse III Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Leguay","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1312, Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire Universit\u00e9 de Bordeaux, CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-227X","authenticated-orcid":false,"given":"Jean","family":"Galtier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1312, Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire Universit\u00e9 de Bordeaux, CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Alric","sequence":"additional","affiliation":[{"name":"Institut Universitaire du Cancer de Toulouse Oncopole, Centre Hospitalier Universitaire de Toulouse Universit\u00e9 Toulouse III Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-8377","authenticated-orcid":false,"given":"Audrey","family":"Bidet","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Delabesse","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique, Institut Universitaire du Cancer de Toulouse Oncopole Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0950-979X","authenticated-orcid":false,"given":"Jean Baptiste","family":"Rieu","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique, Institut Universitaire du Cancer de Toulouse Oncopole Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Vial","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-4404","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Vergez","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique, Institut Universitaire du Cancer de Toulouse Oncopole Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Luquet","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique, Institut Universitaire du Cancer de Toulouse Oncopole Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-5581","authenticated-orcid":false,"given":"Emilie","family":"Klein","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie Biologique CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Charlotte","family":"de Grande","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1312, Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire Universit\u00e9 de Bordeaux, CHU Bordeaux  Bordeaux 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