{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:06:01Z","timestamp":1793279161754,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0510023h0002"],"award-info":[{"award-number":["18ek0510023h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We retrospectively evaluated the impacts of using granulocyte colony\u2010stimulating factor (G\u2010CSF) and its timing on posttransplant outcomes for 9766 adults with acute myeloid leukemia (AML) between 2013 and 2022 using a Japanese database. We separately evaluated three distinct cohorts based on graft type: 3248 received bone marrow transplantation (BMT), 3066 received peripheral blood stem cell transplantation (PBSCT), and 3452 received single\u2010unit cord blood transplantation (CBT). Multivariate analysis showed that G\u2010CSF administration significantly accelerated neutrophil recovery after BMT, PBSCT, and CBT. However, it was associated with a higher risk of grades II\u2013IV acute graft\u2010versus\u2010host disease (GVHD) across all graft types. Moreover, an increased incidence of overall chronic GVHD was observed with G\u2010CSF administration in BMT and CBT patients, but not in PBSCT patients. G\u2010CSF administration significantly improved overall survival (OS) and leukemia\u2010free survival (LFS) only following CBT. Regarding the timing of G\u2010CSF, in comparison with late initiation of G\u2010CSF (Days 5\u201310), early initiation (Days 0\u20134) did not provide benefits for hematopoietic recovery regardless of graft type. In contrast, late initiation was significantly associated with a lower risk of grades II\u2013IV acute GVHD and better OS and LFS in CBT patients. These data demonstrated that G\u2010CSF administration accelerated neutrophil recovery and increased the risk of grades II\u2013IV acute GVHD across all graft types, but significantly improved survival outcomes but only following CBT. Therefore, routine use of G\u2010CSF should be considered for CBT in adult patients with AML.<\/jats:p>","DOI":"10.1002\/ajh.27521","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:13:54Z","timestamp":1732079634000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Different impacts of granulocyte colony\u2010stimulating factor administration on allogeneic hematopoietic cell transplant outcomes for adult acute myeloid leukemia according to graft type"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-8463","authenticated-orcid":false,"given":"Takaaki","family":"Konuma","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, The Institute of Medical Science The University of Tokyo  Tokyo 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