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We analyzed MRD dynamics using next\u2010generation flow in 201 patients treated in clinical trials with chimeric antigen receptor (CAR) T cells and T\u2010cell engagers (TCE). Achieving MRD negativity at 10\n                    <jats:sup>\u22126<\/jats:sup>\n                    was associated with 89% reduction in the risk of progression and\/or death. Survival outcomes were improved in patients with sustained versus transient MRD negativity and were dismal in those who remained MRD positive. The intent\u2010to\u2010treat MRD negative rates were higher in patients treated with CAR T cells versus TCE. However, among patients achieving MRD negativity, there were no differences in survival outcomes when stratified according to treatment with CAR T cells versus TCE. In multivariate analysis including the number of prior lines of treatment, International Staging System, cytogenetic risk, extramedullary disease and type of T\u2010cell redirecting immunotherapy, only the complete remission (CR) and MRD statuses showed independent prognostic value for progression\u2010free and overall survival. In conclusion, our study shows that deep and sustained MRD negative CR is the most relevant prognostic factor and should be considered as the treatment endpoint in RRMM patients treated with CAR T cells and TCE.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27526","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T05:04:37Z","timestamp":1731733477000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical significance of complete remission and measurable residual disease in relapsed\/refractory multiple myeloma patients treated with T\u2010cell redirecting immunotherapy"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-3040","authenticated-orcid":false,"given":"Aintzane","family":"Zabaleta","sequence":"first","affiliation":[{"name":"Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion 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