{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:50:24Z","timestamp":1789159824940,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy has revolutionized treatment of aggressive large B\u2010cell lymphoma (aLBCL). Patients with transformed indolent non\u2010Hodgkin lymphoma (tiNHL) were included in key CAR trials, but outcomes of CAR for this distinct, historically high\u2010risk group are poorly understood. We conducted a multicenter retrospective study of 1182 patients with aLBCL receiving standard\u2010of\u2010care CAR T between 2017 and 2022, including 338 (29%) with tiNHL. Rates of grade \u2265\u20093 cytokine release syndrome (CRS) were similar between tiNHL and de novo cohorts (7% vs. 8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.6), while grade \u2265\u20093 immune effector cell\u2010associated neurotoxicity syndrome was lower in tiNHL (21% vs. 27%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Overall response rate was similar in both cohorts (83% vs. 81%, <jats:italic>p<\/jats:italic>\u2009=\u20090.3), while complete response rate was higher in tiNHL (67% vs. 59%, <jats:italic>p<\/jats:italic>\u2009=\u20090.017). With a median follow\u2010up of 22.3\u2009months, the progression\/relapse\u2010free (PFS) and overall survival (OS) were similar between the tiNHL and de novo cohorts (24\u2010month PFS 41% [95% CI: 35%\u201346%] vs. 38% [95% CI: 35%\u201342%]; 24\u2010month OS 58% [95% CI: 52%\u201363%] vs. 52% [95% CI: 48%\u201356%], respectively). After adjusting for key risk factors, there was a trend toward a lower hazard of disease progression, relapse or death post\u2010CAR for tiNHL patients compared to de novo aLBCL patients (HR: 0.84 [95% CI: 0.69\u20131.0], <jats:italic>p<\/jats:italic>\u2009=\u20090.07). Elevated LDH, advanced stage, prior bendamustine within 12\u2009months of CAR, receipt of bridging therapy, CNS involvement, and \u2265\u20093 prior lines of therapy were each associated with inferior PFS. In conclusion, CAR T therapy is highly effective with an acceptable toxicity profile in patients with tiNHL.<\/jats:p>","DOI":"10.1002\/ajh.27548","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T17:35:05Z","timestamp":1734975305000},"page":"236-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes of <scp>CD19 CAR<\/scp> T in Transformed Indolent Lymphoma Compared to De Novo Aggressive Large B\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-3274","authenticated-orcid":false,"given":"Swetha Kambhampati","family":"Thiruvengadam","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California 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