{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:03Z","timestamp":1787755983539,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chronic hemolysis potentially elevates the risk of gallstones in several types of congenital red blood cell (RBC) disorders. However, the magnitude of the risk is unknown. We investigate the risk of gallstone disease in congenital RBC disorder patients, compared with general population comparators. Patients were identified from the Danish National Patient Registry covering all Danish hospitals and the National Reference Laboratory for RBC disorders during 1980\u20132016. Patients were matched by sex, age, and region of origin with up to 50 general population comparators. Gallstone events were identified using hospital\u2010registered diagnoses and surgery codes. Our study included 9354 congenital RBC disorder patients, grouped according to type of congenital RBC disorder, and 416\u2009994 general population comparators. The cumulative 10\u2010year incidence of gallstone disease was 4.2% in patients with congenital RBC disorders and 1.7% among comparators. Adjusted csHR's [95% confidence interval] were 8.1 [6.8, 9.7] for hereditary spherocytosis; 3.3 [1.6, 6.8] for glucose\u20106\u2010phosphate dehydrogenase deficiency; 21.6 [10.6, 44.1] for pyruvate kinase deficiency; 3.7 [1.9, 7.0] for sickle cell disease; 0.8 [0.4, 1.6] for sickle cell trait; 1.5 [1.1, 2.2] for \u03b1\u2010thalassemia trait; 1.8 [1.4, 2.3] for \u03b2\u2010thalassemia minor; and 2.1 [1.8, 2.6] for other congenital hemolysis. We found a markedly higher risk of hospital\u2010registered gallstone diseases in nearly all groups of patients with congenital RBC disorders compared with the general population.<\/jats:p>","DOI":"10.1002\/ajh.27558","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T13:46:44Z","timestamp":1733752004000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["10\u2010Year Risk of Gallstones in Congenital Red Blood Cell Disorder Patients: A Nationwide Cohort Study"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0397-357X","authenticated-orcid":false,"given":"Anders Blach","family":"Naamansen","sequence":"first","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-1297","authenticated-orcid":false,"given":"Dennis Lund","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-5114","authenticated-orcid":false,"given":"Jesper","family":"Petersen","sequence":"additional","affiliation":[{"name":"Hematologic Laboratory, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-0738","authenticated-orcid":false,"given":"Andreas","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Danish Red Blood Cell Center, Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-7040","authenticated-orcid":false,"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-0220","authenticated-orcid":false,"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S250251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510601046557"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"issue":"8","key":"e_1_2_9_6_1","first-page":"704","article-title":"Inherited Haemoglobin Disorders: An Increasing Global Health Problem","volume":"79","author":"Weatherall D. 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