{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:40:30Z","timestamp":1785393630432,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013412","name":"Sanofi Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Managing acute venous thromboembolism (VTE) in patients with thrombocytopenia is challenging. We used data from the RIETE registry to investigate the impact of baseline thrombocytopenia on early VTE\u2010related outcomes, depending on the initial presentation as pulmonary embolism (PE) or isolated lower\u2010limb deep vein thrombosis (DVT). From March 2003 to November 2022, 90\u2009418 patients with VTE were included. Thrombocytopenia was categorized as severe (&lt;\u200950\u2009000\/\u03bcL, <jats:italic>n<\/jats:italic>\u2009=\u2009303) or moderate (50\u2009000\u201399\u2009999\/\u03bcL, <jats:italic>n<\/jats:italic>\u2009=\u20091882). The primary outcome, fatal PE within 15\u2009days after diagnosis, and secondary outcomes, including major bleeding and recurrent VTE, were analyzed using multivariable\u2010adjusted models. Among 52\u2009703 patients with PE, the 15\u2010day case\u2010fatality rates from PE were 5.8% for severe thrombocytopenia, 4.5% for moderate thrombocytopenia, and 1.1% for normal platelet counts. In 37\u2009715 patients with isolated DVT, the cumulative incidence of fatal PE were 0, 0.2%, and 0.05%, respectively. Multivariable analysis revealed a five\u2010fold increase in the risk for fatal PE in severe thrombocytopenia (adjusted HR: 4.89; 95%CI: 2.55\u20139.39) without significant differences between severe and moderate thrombocytopenia. Thrombocytopenia, either moderate or severe, was also associated with increased risk for both, major bleeding and recurrent VTE at 15\u2009days. Initial presentation with PE substantially worsened prognosis compared to isolated DVT. In conclusion, in patients with acute VTE, thrombocytopenia at baseline was associated with increased risk of early death from PE, a finding that was driven by the subgroup whose initial presentation was PE.<\/jats:p>","DOI":"10.1002\/ajh.27579","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T07:21:11Z","timestamp":1736493671000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Baseline Thrombocytopenia on Early Outcomes in Patients With Acute Venous Thromboembolism"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-8866","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Lecumberri","sequence":"first","affiliation":[{"name":"Department of Hematology Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Ruiz\u2010Artacho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cl\u00ednica Universidad de Navarra  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Trujillo\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Universitario Santa Luc\u00eda, Cartagena, Murcia. Universidad Cat\u00f3lica San Antonio de Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Marcos\u2010Jubilar","sequence":"additional","affiliation":[{"name":"Department of Hematology Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"P\u00e9rez\u2010Pinar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Virgen de la Luz  Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Qu\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, H\u00f4pital Saint Eloi Centre Hospitalier Universitaire de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Claver","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Sant Camil  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gorostidi","sequence":"additional","affiliation":[{"name":"Department of Pneumonology Hospital Universitario de Cabue\u00f1es  Gij\u00f3n Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-879X","authenticated-orcid":false,"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA. Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA. YNHH\/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, CT, USA Cardiovascular Research Foundation (CRF)  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[{"name":"Chair for the Study of Thromboembolic Disease, Faculty of Health Sciences UCAM \u2010 Universidad Cat\u00f3lica San Antonio de Murcia  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The RIETE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0352"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008644"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001830"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00160-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.014"},{"issue":"8","key":"e_1_2_9_8_1","article-title":"EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer","volume":"6","author":"Falanga A.","year":"2022","journal-title":"Hema"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-07-0480"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1777-4006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2021.08.015"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"834","article-title":"Dynamics of Case\u2010Fatality Rates of Recurrent Thromboembolism and Major Bleeding in Patients Treated for Venous Thromboembolism","volume":"110","author":"Lecumberri R.","year":"2013","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.07.021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15748"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005966"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.05.012"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:09:53Z","timestamp":1754906993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ajh.27579"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27579","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"2024-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}