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Overall, there was a significant, negative and strong association between MRD negativity odds ratios and survival hazard ratios (\u03b2_PFS\u2009=\u2009\u20100.20, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, \u03b2_OS\u2009=\u2009\u20100.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.023). These associations remained significant for newly diagnosed patients (\u03b2_PFS\u2009=\u2009\u20100.35, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and they were consistent but not significant for relapsed\/refractory patients (\u03b2_PFS\u2009=\u2009\u20100.06, <jats:italic>p<\/jats:italic>\u2009=\u20090.635). Sustained MRD negativity at 1\u2009year was strongly correlated with prolonged PFS (\u03b2_PFS\u2009=\u2009\u20100.30, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, this comprehensive meta\u2010analysis supports MRD as a surrogate for survival in MM.<\/jats:p>","DOI":"10.1002\/ajh.27582","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T07:07:34Z","timestamp":1736406454000},"page":"427-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Evaluating Minimal Residual Disease Negativity as a Surrogate Endpoint for Treatment Efficacy in Multiple Myeloma: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-9783","authenticated-orcid":false,"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens 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