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There were 57\u2009288 reported therapeutic error\u2010related exposures involving antithrombotic medications as the primary substance. The rate of therapeutic errors increased by 590.9% during this 22\u2010year period. Although most (90.1%) therapeutic errors were clinically inconsequential and did not receive treatment at a healthcare facility, 2.3% were medically admitted, and 2.1% experienced a serious medical outcome, including 16 fatalities. Three\u2010fourths (74.9%) of therapeutic errors were among &gt;\u200959\u2010year\u2010olds, and females represented 58.0% of exposures. Warfarin was the most commonly involved antithrombotic medication (37.5%), followed by direct oral anticoagulants (DOACs, 28.7%) and clopidogrel (23.3%). Therapeutic errors involving warfarin were more likely to be associated with a medical admission (odds ratio [OR]\u2009=\u20092.23; 95% confidence interval [CI]: 1.99\u20132.49) or a serious medical outcome (OR\u2009=\u20092.99; 95% CI: 2.65\u20133.37), and DOACs were less likely to be associated with a medical admission (OR\u2009=\u20090.53, 95% CI: 0.46\u20130.61) or a serious medical outcome (OR\u2009=\u20090.45; 95% CI: 0.38\u20130.53) than therapeutic errors involving other antithrombotic medications. The rate of therapeutic errors involving warfarin significantly increased by 187.0% during 2000\u20132011, followed by a 57.6% significant decrease during 2011\u20132021. The rate of therapeutic errors involving DOACs increased significantly by 1118.2% during 2011\u20132021. The scenario \u201cinadvertently took\/given medication twice\u201d accounted for 56.3% of all therapeutic errors. Increased risk reduction efforts are needed to prevent antithrombotic\u2010related therapeutic errors.<\/jats:p>","DOI":"10.1002\/ajh.27595","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T08:06:31Z","timestamp":1737101191000},"page":"561-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Errors Associated With Antithrombotic Medications Reported to United States Poison Centers"],"prefix":"10.1002","volume":"100","author":[{"given":"Emma N.","family":"Cravo","sequence":"first","affiliation":[{"name":"Center for Injury Research and Policy The Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Rocky Vista University College of Osteopathic Medicine  Ivins Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Hays","sequence":"additional","affiliation":[{"name":"Center for Injury 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