{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:28:14Z","timestamp":1790083694070,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Both anti\u2010T\u2010lymphocyte globulin (ATLG\u2010Grafalon) and anti\u2010thymocyte globulin (ATG\u2010Thymoglobulin) prevent acute and chronic graft\u2010versus\u2010host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Despite distinct manufacturing and biological characteristics, the two brands of rabbit anti\u2010lymphocyte globulins have never been compared in a prospective way. In this monocentric study, 114 adult patients transplanted with a matched related or unrelated donor after receiving either ATG (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950) or ATLG (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200964) were included to compare their clinical outcomes and broad immune reconstitution parameters. The use of ATLG, compared with ATG, was associated with a 2\u2010fold reduction in Grade II\u2013IV acute GvHD incidence (Cox HR\u2009=\u20090.29; 95% CI 0.14\u20130.62,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), similar relapse incidence, and improved severe GvHD and relapse\u2010free survival (GRFS) (Cox HR\u2009=\u20090.51; 95% CI 0.29\u20130.91,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). Biologically, reduced IL\u201015 but increased IL\u201021 serum concentrations and a significant reduction of PD1+ T cells, mainly across all differentiated stages of CD8+ T cells, were observed in the ATLG group. Immunosequencing of v\u03b2 T cell receptor (TCR) repertoires showed similar quantitative characteristics in terms of clonality and diversity across the two groups but different qualitative features, with reduced hyper\u2010expanded T cell clones and higher variability in the distribution of complementarity\u2010determining region 3 (CDR3) lengths in the ATLG group. Altogether, these results suggest that ATLG more effectively regulates alloreactive T cell activation, leading to better prevention of acute GvHD while preserving the graft\u2010versus\u2010leukemia response. These findings led us to initiate a multicentric Phase III randomized trial comparing the two anti\u2010lymphocyte globulins.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    The biological REAL GREFFE study was registered in clinicaltrial.gov under the number: NCT03357172.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27619","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T02:30:26Z","timestamp":1738722626000},"page":"626-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Differential Clinical and Immunological Impacts of Anti\u2013T\u2010Lymphocyte Globulin (\n                    <scp>ATLG<\/scp>\n                    ) vs. Anti\u2010Thymocyte Globulin (\n                    <scp>ATG<\/scp>\n                    ) in Preventing Graft\u2010Versus\u2010Host Disease Post\u2010Allogeneic Hematopoietic Stem Cell Transplantation: A Comparative Study"],"prefix":"10.1002","volume":"100","author":[{"given":"Anne Beatrice","family":"Notarantonio","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"},{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Morisset","sequence":"additional","affiliation":[{"name":"Biostatistics Independent Consultant  P\u00e9rouges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Piucco","sequence":"additional","affiliation":[{"name":"Inserm U1256 N\u2010GERE University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"P\u00e9r\u00e8s","sequence":"additional","affiliation":[{"name":"Laboratoire d'histocompatilit\u00e9\u2010HLA H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Boulang\u00e9","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliz\u00e9e","family":"Alitcher","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Brouard","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Monchablon","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Campidelli","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"El Ouahabi","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Guisnel","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charline","family":"Moulin","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Kicki","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Roth\u2010Guepin","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Feugier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"},{"name":"Inserm U1256 N\u2010GERE University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo De Carvalho","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"},{"name":"Laboratoire d'Immunologie H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Aarnink","sequence":"additional","affiliation":[{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"},{"name":"Laboratoire d'histocompatilit\u00e9\u2010HLA H\u00f4pital Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-2742","authenticated-orcid":false,"given":"Maud","family":"D'Aveni\u2010Piney","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"},{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-7992","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Hergalant","sequence":"additional","affiliation":[{"name":"Inserm U1256 N\u2010GERE University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pagliuca","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"},{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-5442","authenticated-orcid":false,"given":"Marie Th\u00e9r\u00e8se","family":"Rubio","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie H\u00f4pital Brabois  Nancy France"},{"name":"CNRS UMR 7365, IMoPA, Biop\u00f4le de l'Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004383"},{"issue":"6","key":"e_1_2_11_3_1","first-page":"586","article-title":"Acute Graft\u2010Versus\u2010Host Disease","volume":"378","author":"Zeiser R.","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70225-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-329821"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.8177"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.12.034"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00462-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0792-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404683"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148510"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.11.014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-130146"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03978.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251975.81281.22"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122081"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030382"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12514"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199504270-00020"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.08.027"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704957"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1045901"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1439584"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00315"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16101891"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01666-x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.001"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-609032"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001077"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.13"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27858"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30029-7"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.08.029"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12141831"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211063783"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.06.005"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.715243"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.002"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401687"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.271445"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.747324"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610115104"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1687"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1597"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7634.1"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0490-3"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0221-9"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.03.022"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01034"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03322.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-176594"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T05:06:20Z","timestamp":1752901580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ajh.27619"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27619","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}