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We sought to determine the cost\u2010effectiveness of screening versus no screening for ID in women of reproductive age in the United States. A lifetime simulation of women of reproductive age was conducted using a Markov cohort model\u00a0under three strategies: (1) no screening, (2) screening at a ferritin threshold of 15\u2009\u03bcg\/L, and (3) screening at a ferritin threshold of 25\u2009\u03bcg\/L, from the US health system perspective, and at a willingness\u2010to\u2010pay threshold of $100\u2009000\/quality\u2010adjusted life year (QALY). Epidemiologically informed ID prevalence estimates sourced from the National Health and Nutrition Examination Survey were employed for model parameterization. The primary outcome was the incremental cost\u2010effectiveness ratio (ICER, in $\/QALY). Base\u2010case results for the three strategies accrued $209\u2009700, $210\u2009200, and $210\u2009200 discounted lifetime costs and 23.6, 24.0, and 24.4 discounted lifetime QALYs, respectively. Screening at a ferritin threshold of 25\u2009\u03bcg\/L was the cost\u2010effective intervention with an ICER of $680\/QALY (95% credible interval $350\u2013$750\/QALY). In dual base\u2010case analyses examining intravenous rather than oral iron repletion for treatment, screening at a ferritin threshold of 25\u2009\u03bcg\/L remained the cost\u2010effective intervention with an ICER of $2300\/QALY (95% CI $1800\u2013$3800\/QALY). In probabilistic sensitivity analyses, screening at a ferritin threshold of 25\u2009\u03bcg\/L was the cost\u2010effective intervention in 100% of 10\u2009000\u2009second order Monte Carlo iterations.<\/jats:p>","DOI":"10.1002\/ajh.27686","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T03:30:46Z","timestamp":1744774246000},"page":"1132-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cost\u2010Effectiveness of Ferritin Screening Thresholds for Iron Deficiency in Reproductive\u2010Age Women"],"prefix":"10.1002","volume":"100","author":[{"given":"Daniel","family":"Wang","sequence":"first","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manraj","family":"Sra","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Glaeser\u2010Khan","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Yale College  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranya","family":"Moshashaian\u2010Asl","sequence":"additional","affiliation":[{"name":"University of Vermont Larner College of Medicine  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Ito","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology &amp; 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