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A total of 316 ALL patients aged \u2265\u200960\u2009years who underwent alloHSCT between 2010 to 2022 were identified in the SFGM\u2010TC registry. The primary objective was to evaluate progression\u2010free survival (PFS), non\u2010relapse mortality (NRM), relapse incidence (RI), and graft\u2010versus\u2010host disease (GvHD)\u2010free relapse\u2010free survival (GRFS), as well as their risk factors. The median age was 63.8\u2009years (range 60\u201375.8), 49.8% of patients had Philadelphia\u2010positive B\u2010ALL (Ph\u2009+\u2009ALL), and 70.9% were in first complete remission (CR1) at transplantation. The donor was an unrelated donor in 52.1%, a matched related donor (MRD) in 26.3%, and a haplo\u2010identical donor in 17.7%. Reduced\u2010intensity conditioning (RIC) was administered to 64.6% of patients, while total body irradiation (TBI) was used in 35.8%. The 3\u2010year overall survival (OS) was 46% (95% CI 40%\u201353%). The 3\u2010year PFS, NRM, RI, and GRFS were 41% (95% CI 35%\u201348%), 23% (95% CI 18%\u201328%), 36% (95% CI 31%\u201342%), and 30% (95% CI 25%\u201337%), respectively. Multivariable analyses confirmed poorer OS and PFS in patients with advanced disease, with an HR of 1.79 (95% CI 1.22\u20132.64), <jats:italic>p<\/jats:italic>\u2009=\u20090.0032. Additionally, the ALL subtype significantly impacted outcomes, with an HR of 1.99 (95% CI 1.42\u20132.79) for non\u2010Ph\u2009+\u2009ALL. This study suggests that alloHSCT is a viable option for elderly ALL patients, as age itself did not impact outcomes. However, advanced disease and non\u2010Ph\u2009+\u2009ALL were associated with significantly worse survival.<\/jats:p>","DOI":"10.1002\/ajh.27701","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T07:08:38Z","timestamp":1746515318000},"page":"1173-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Allogeneic Hematopoietic Stem Cell Transplantation for Elderly Acute Lymphoblastic Leukemia Patients: A Registry Study From the Soci\u00e9t\u00e9 Francophone de Greffe de Moelle et Th\u00e9rapie Cellulaire (<scp>SFGM<\/scp>\u2010<scp>TC<\/scp>)"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-8104","authenticated-orcid":false,"given":"Yves","family":"Chalandon","sequence":"first","affiliation":[{"name":"University Hospital Geneva, Hematology Service and Faculty of Medicine, University of Geneva  Geneva 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