{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:12Z","timestamp":1786976712056,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010210","name":"Defense Human Resources Activity","doi-asserted-by":"publisher","award":["CA220385"],"award-info":[{"award-number":["CA220385"]}],"id":[{"id":"10.13039\/100010210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA233945"],"award-info":[{"award-number":["R01CA233945"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA195568"],"award-info":[{"award-number":["U01 CA195568"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:sup>18<\/jats:sup>\n                    Fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) is the standard imaging modality in lymphoma. The 2014 Lugano classification considers extranodal marginal zone lymphoma (EMZL) a non\u2010FDG\u2010avid disease, recommending contrast\u2010enhanced CT. We reassessed the utility of PET\/CT for staging workup and response assessment of EMZL. We reviewed staging and response PET\/CT of 190 EMZL sites from 152 patients. Each location was counted independently for patients with &gt;\u20091 extranodal site. Although not standard, we considered FDG\u2010avid disease if SUVmax was \u2265\u20092, and calculated ratios between lymphoma SUVmax and mediastinal blood pool (BP index) and liver background (liver index). FDG avidity was detected in 151 (79.5%) out of 190 extranodal sites (in 117 [76.7%] out of 152 patients), with a median SUVmax of 4.5 (IQR 2.5\u20136.9, range 0\u201326.8). Locations showing FDG avidity in &gt;\u200990% of extranodal sites included salivary gland, bone, lung, soft tissue, ocular adnexa, and airways. Skin was commonly non\u2010FDG avid (93.8%). Among 22 patients with &gt;\u20091 extranodal location, there was concordant FDG avidity in all sites in 18 (81.8%) patients. Considering measurable extranodal disease size &gt;\u20090.5\u2009cm, we observed significant Pearson correlation coefficients (\n                    <jats:italic>r<\/jats:italic>\n                    ) between lymphoma size and SUVmax (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.20,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009142), BP index (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.34,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009124), and liver index (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.36,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009124). We also observed improved precision in response to treatment assessment in FDG\u2010avid EMZL tumors. This study demonstrates that EMZL is commonly an FDG\u2010avid disease, suggesting that PET\/CT should be routinely used in the staging and response assessment workup of patients with EMZL.\n                  <\/jats:p>","DOI":"10.1002\/ajh.27712","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:35:23Z","timestamp":1747816523000},"page":"1295-1304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    in the Staging and Treatment Response Assessment of Patients With Extranodal Marginal Zone Lymphoma"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-3377","authenticated-orcid":false,"given":"Juan Pablo","family":"Alderuccio","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ A.","family":"Kuker","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Division of Radiology University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Edelman Saul","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele D.","family":"Stanchina","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Polar","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Division of Radiology University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Chapman","sequence":"additional","affiliation":[{"name":"Division of Hematopathology, Department of Pathology University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Shared Resource Sylvester Comprehensive Cancer Center  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9002-6426","authenticated-orcid":false,"given":"Rafael","family":"Hennemann Sassi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H.","family":"Moskowitz","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isildinha M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Shared Resource Sylvester Comprehensive Cancer Center  Miami Florida USA"},{"name":"Department of Public Health Sciences University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-9013","authenticated-orcid":false,"given":"Izidore S.","family":"Lossos","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, 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