{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:52:52Z","timestamp":1789501972910,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sinusoidal obstruction syndrome\/veno\u2010occlusive disease (SOS\/VOD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). According to the 2016 European Society for Blood and Marrow Transplantation criteria, SOS\/VOD is classified into classical SOS\/VOD and late\u2010onset SOS\/VOD, but their similarities and differences remain unclear. Here we retrospectively investigated the incidence, risk factors, and impact on transplant outcomes of classical and late\u2010onset SOS\/VOD in 16\u2009518 allo\u2010HSCT recipients using the Japanese nationwide registry data. The cumulative incidences of classical and late\u2010onset SOS\/VOD were 2.5% and 2.2%, with a median onset of 13 and 42\u2009days after transplantation, respectively. Both patients with classical (hazard ratio [HR], 3.45; 95% CI, 3.07\u20133.87) and late\u2010onset (HR, 3.98; 95% CI, 3.51\u20134.51) SOS\/VOD had a significantly worse overall survival compared with those without. The risk factors for classical and late\u2010onset SOS\/VOD are different. Hepatic comorbidities, high\u2010risk diseases, use of melphalan (MEL), and myeloablative conditioning are associated with both types of SOS\/VOD. Whereas poor performance status, a prior history of transplantation, and positive hepatitis C virus are associated with only classical SOS\/VOD, allo\u2010HSCT from cord blood or related human leukocyte antigen\u2010haploidentical donors, use of total body irradiation and busulfan (BU), and tacrolimus\u2010based graft\u2010versus\u2010host disease prophylaxis are associated with only late\u2010onset SOS\/VOD. In particular, the incidence of late\u2010onset SOS\/VOD is much higher in patients receiving both BU\u2010 and MEL\u2010containing conditioning regimens. These findings suggest that different monitoring and treatment approaches are necessary for allo\u2010HSCT recipients at high risk for classical and late\u2010onset SOS\/VOD.<\/jats:p>","DOI":"10.1002\/ajh.27715","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:01:18Z","timestamp":1747645278000},"page":"1283-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Classical and Late\u2010Onset <scp>SOS<\/scp>\/<scp>VOD<\/scp> After Allogeneic <scp>HSCT<\/scp>: A Japanese Transplant Registry Analysis"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0811-2647","authenticated-orcid":false,"given":"Kyoko","family":"Masuda","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Keio University School of Medicine  Tokyo 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