{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:03:12Z","timestamp":1788732192633,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this multi\u2010institutional retrospective study, we analyzed the characteristics and outcomes of 118 patients with solitary bone plasmacytoma (SBP) and 57 with extramedullary plasmacytoma (SEP) diagnosed over 30\u2009years. We also evaluated the impact of systemic therapy (ST), which is not routinely recommended, compared to standard radiation therapy (RT). The median age was 62\u2009years (range: 17\u201385). Treatment included RT (<jats:italic>n<\/jats:italic>\u2009=\u200994), RT with ST (<jats:italic>n<\/jats:italic>\u2009=\u200947), ST alone (<jats:italic>n<\/jats:italic>\u2009=\u200922), and surgical excision alone (<jats:italic>n<\/jats:italic>\u2009=\u200912). Overall and complete response (CR) rates were 93% and 53%, respectively; 70 patients relapsed, 56 progressing to multiple myeloma (MM). The median follow\u2010up was 10\u2009years (95% CI: 7.1\u201313). Median estimated overall survival (OS) was 18.5\u2009years with a 5\u2010 and 10\u2010year OS rate of 85% and 70%, respectively, similar across groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Median progression\u2010free survival (PFS) was 75\u2009months (95% CI: 53\u201397), with a 5\u2010 and 10\u2010year PFS rates of 57% and 44%. The 5\u2010 and 10\u2010year MM\u2010free survival (MMFS) was 66% and 53%, respectively. We identified age\u2009\u2264\u200960\u2009years, achieving CR, and an abnormal serum FLC ratio at diagnosis as the strongest prognosticators for OS (HR: 0.25), PFS (HR: 0.54), and MMFS (HR: 5 + 0.4), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); ST alone or combined with RT did not significantly improve survival outcomes or MMFS (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In conclusion, ST increased toxicity without offering outcome benefits, reaffirming RT as the cornerstone of SP management. Despite therapeutic advancements in MM, the persistent challenge of progression to MM underscores the importance of identifying high\u2010risk SP patients, enabling early intervention with more aggressive treatments.<\/jats:p>","DOI":"10.1002\/ajh.27725","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T22:43:53Z","timestamp":1748990633000},"page":"1334-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics and Survival Outcomes of Solitary Plasmacytomas: A 30\u2010Year Experience of the Greek Myeloma Study Group on 175 Patients"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-807X","authenticated-orcid":false,"given":"Eirini","family":"Katodritou","sequence":"first","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-5832","authenticated-orcid":false,"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-4716","authenticated-orcid":false,"given":"Dimitra","family":"Dalampira","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kanellias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Labropoulou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Kyriakidis","sequence":"additional","affiliation":[{"name":"Department of Hematology Agios Savvas Cancer Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Douka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Unit Papanikolaou General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-7510","authenticated-orcid":false,"given":"Sosana","family":"Delimpasi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Unit Evangelismos Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysios","family":"Stoumbos","sequence":"additional","affiliation":[{"name":"Department of Haematology Metaxa Cancer Hospital  Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Spanoudakis","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Alexandroupolis  Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-837X","authenticated-orcid":false,"given":"Sotirios","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Department of Hematology Attikon General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annita\u2010Ioanna","family":"Gkioka","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine, Laikon General Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-9783","authenticated-orcid":false,"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosia","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Tsirou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki","family":"Sevastoudi","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Daiou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-0351","authenticated-orcid":false,"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3482-4286","authenticated-orcid":false,"given":"Nikolaos","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Thessaly  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-9424","authenticated-orcid":false,"given":"Vasiliki","family":"Pappa","sequence":"additional","affiliation":[{"name":"Department of Hematology Attikon General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avgi","family":"Lalayianni","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Unit Papanikolaou General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Pouli","sequence":"additional","affiliation":[{"name":"Department of Hematology Agios Savvas Cancer Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Kyrtsonis","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine, Laikon General Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kotsopoulou","sequence":"additional","affiliation":[{"name":"Department of Haematology Metaxa Cancer Hospital  Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Verrou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-1229","authenticated-orcid":false,"given":"Maria","family":"Gavriatopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-1422","authenticated-orcid":false,"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8990-3254","authenticated-orcid":false,"given":"Meletios\u2010Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Medicine Korea University Seoul  South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11864\u2010002\u20100015\u20102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70442\u20105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102141.2008.07421.X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12885\u2010016\u20103015\u20105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13045\u2010017\u20100549\u20101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19920315)69:6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1069(199609)14:3<111::AID-HON575>3.0.CO;2-G"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(96)00334\u20103"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/BJC.1995.26"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.27422"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41408\u2010022\u201000730\u20105"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.26891"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.27425"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/EJH.12907"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJROBP.2005.06.039"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/OXFORDJOURNALS.ANNONC.A059285"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.23201"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102014\u201004\u2010567909"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNCR.10366"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102006\u201004\u2010015784"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41375\u2010018\u20100099\u20108"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.14291"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/HON.2415"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.13870"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.14189"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.23745"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.26557"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/HAEMATOL.2022.282214"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2023021187"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201013\u20102910"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2023021859"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.21211"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJROBP.2018.05.009"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJROBP.2019.10.043"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100609.2004.00404.X"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.21248"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2021.755866"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.27725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:02:55Z","timestamp":1759136575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.27725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ajh.27725"],"URL":"https:\/\/doi.org\/10.1002\/ajh.27725","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}