{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:32:09Z","timestamp":1756996329921},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":11149,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular and humoral factors involved in the regulation of granulopoiesis were evaluated in two patients with cyclic neutropenia by utilizing the agar\u2010gel marrow culture technique to serially study marrow granulocytic colony\u2010forming capacity (CFC) and the urinary output of colony\u2010stimulating factor (CSF). CSF output varied inversely with peripheral neutrophil counts and directly with monocyte counts and evidence for infection (endotoxemia and\/or staphylococcal abscesses). Following autologous infusion of one patient's plasma obtained during a period of neutropenia, increased urinary excretion of CSF occurred concomitant with increments in both marrow CFC and the proportion of granulocytic progenitor cells in DNA synthesis. Neutrophil periodicity was not altered by the administration of the neutropenic plasma. These findings are consistent with the hypothesis that cyclic neutropenia is caused by a quantitatively decreased entry of stem cells or granulocytic progenitor cells into granulopoiesis.<\/jats:p>","DOI":"10.1002\/ajh.2830010403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:38:48Z","timestamp":1172032728000},"page":"375-385","source":"Crossref","is-referenced-by-count":14,"title":["Alteration of colony\u2010stimulating factor output, endotoxemia, and granulopoiesis in cyclic neutropenia"],"prefix":"10.1002","volume":"1","author":[{"given":"Peter L.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ine","family":"Bax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony M.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040790203"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106693"},{"key":"e_1_2_1_4_2","first-page":"103","article-title":"Mechanisms of leukocyte production and release. VI. Studies on the purification of the leukocytosis\u2010inducing factor","volume":"3","author":"Katz R","year":"1966","journal-title":"J Reticulo Endothel Soc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-127-32774"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1182\/blood.V37.6.647.647","article-title":"Neutrophika\u2010inducing activity in plasma of neutropenic human beings","volume":"37","author":"Marsh JC","year":"1971","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/blood.V36.2.254.254","article-title":"Computer simulation of granulopoiesis: Normal and impaired granulopoiesis","volume":"6","author":"King\u2010Smith EA","year":"1970","journal-title":"Blood 3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197003192821202"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107636"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4120.83"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107522"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1966.28"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040760111"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1971.65"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040780314"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040800114"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040790204"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(66)90026-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040690111"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1968.tb01524.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1969.51"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197006042822304"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-134-34871"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood.V41.6.753.753","article-title":"Granulopoiesis in neutropenic disorders","volume":"41","author":"Greenberg PL","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1182\/blood.V37.1.14.14","article-title":"Studies on the regulation of granulopoiesis. IV. Possible humordl regulation","volume":"37","author":"Morley A","year":"1971","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1182\/blood.V37.1.6.6","article-title":"The in vitro colony forming cell and the response to neutropenia","volume":"37","author":"Rickard KA","year":"1971","journal-title":"Blood"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1971.tb02709.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1182\/blood.V41.3.391.391","article-title":"Effect of endotoxin on granulopoiesis and the in vitro colony\u2010forming cell","volume":"41","author":"Quesenberry PJ","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-134-34721"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197106032842201"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1182\/blood.V44.3.375.375","article-title":"Alterations of granulopoiesis following chemotherapy","volume":"44","author":"Greenberg PL","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_32_2","first-page":"903","article-title":"Detection of endotoxin in human blood and demonstration of an inhibitor","volume":"75","author":"Levin J","year":"1970","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_33_2","first-page":"138","article-title":"Quantitative comparison of in vitro and in vivo methods for the detection of endotoxin","volume":"78","author":"Cooper JF","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.25.020174.001413"},{"key":"e_1_2_1_35_2","first-page":"275","article-title":"Humoral and cellular alterations in cyclic neutropenia (abstract)","volume":"23","author":"Greenberg PL","year":"1975","journal-title":"Clin Res"},{"key":"e_1_2_1_36_2","first-page":"211","volume-title":"Hemopoietic Cellular Proliferation","author":"Cronkite EP","year":"1970"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06773.x"},{"key":"e_1_2_1_38_2","first-page":"235","article-title":"Growth and responsiveness of human granulocytic leukemic cells in vitro","volume":"40","author":"Metcalf D","year":"1975","journal-title":"Bib1 Haemat"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1182\/blood.V42.5.701.701","article-title":"Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells","volume":"42","author":"Messner H","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-149-38911"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1974.tb00213.x"},{"key":"e_1_2_1_42_2","first-page":"157","article-title":"Stimulation by human urine or plasma of granulopoiesis by human marrow cells in agar","volume":"2","author":"Metcalf D","year":"1974","journal-title":"Exp Hemat"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197202032860502"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-140-36484"},{"key":"e_1_2_1_45_2","first-page":"427","article-title":"Acute antigen\u2010induced elevation of serum colony stimulating factor (CSF) levels","volume":"21","author":"Metcalf D","year":"1971","journal-title":"Immunology"},{"key":"e_1_2_1_46_2","first-page":"280","article-title":"Serum colony stimulating factor (CSF) responses in tolerant and infected mice (abstract)","volume":"23","author":"Quesenberry P","year":"1975","journal-title":"Clin Res"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107124"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4057.164"},{"key":"e_1_2_1_49_2","first-page":"949","article-title":"The effect of endotoxin on colony stimulating factor (CSF) release from granulocytes and monocytes in vitro (abstract)","volume":"40","author":"Hay EG","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-1-1"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197311012891801"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/128.4.551"},{"key":"e_1_2_1_53_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4049\/jimmunol.115.2.599","article-title":"Concanavalin A preparations with activities related to bacterial lipopolysaccharide","volume":"115","author":"Brunson KD","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34268"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35572"},{"key":"e_1_2_1_56_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1128\/am.26.1.43-48.1973","article-title":"Preparation, sensitivity and specificty of Limulus lysate for endotoxin assay","volume":"26","author":"Jorgensen JH","year":"1973","journal-title":"Appl Microbiol"},{"key":"e_1_2_1_57_2","first-page":"513","article-title":"Role of the intestinal flora in clearance and detoxification of circulating endotoxin","volume":"14","author":"Caridis DT","year":"1973","journal-title":"J Reticulo Endothel Soc"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830010403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830010403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:56:41Z","timestamp":1699847801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830010403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1002\/ajh.2830010403"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830010403","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}