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An antiplatelet antibody requiring the presence of an appropriate drug for interaction with platelets was demonstrated in each case by the <jats:sup>51<\/jats:sup>Cr platelet lysis test using normal, paroxysmal nocturnal hemoglobinuric, or enzyme\u2010treated normal platelets as target cells. These antibodies could not be detected by techniques that depend on clot retraction inhibition, complement fixation, or platelet factor\u20103 activation. Quinine\u2010 and quinidine\u2010dependent antiplatelet antibodies in the serum of 16 patients who developed acute thrombocytopenia while taking either quinine or quinidine could be demonstrated readily with the <jats:sup>51<\/jats:sup>Cr platelet lysis test and could also be detected by other methods employed.<\/jats:p>","DOI":"10.1002\/ajh.2830020109","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:36:25Z","timestamp":1172032585000},"page":"65-72","source":"Crossref","is-referenced-by-count":52,"title":["Detection of drug\u2010dependent antibodies by the <sup>51<\/sup>cr platelet lysis test: Documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole"],"prefix":"10.1002","volume":"2","author":[{"given":"Philip L.","family":"Cimo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony 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