{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:41:37Z","timestamp":1787755297525,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A critical factor limiting the availability of histocompatible platelet transfusions for alloimmunized, thrombocytopenic patients is the large pool of HL\u2010typed donors needed to procure platelets perfectly matched for HLA antigens. We have, therefore, investigated the effectiveness of platelets obtained from donors having lesser degrees of histocompatibility. In 421 transfusions administered to 59 alloimmunized patients who were refractory to \u201crandom donor\u201d platelets, it was found that platelets mismatched for 1 or 2 \u201ccross\u2010reactive\u201d HLA antigens were in most instances as effective in increasing circulating platelet levels as perfectly matched platelets. A significant number of patients also responded to platelets from donors selectively mismatched for non\u2010cross\u2010reactive HLA antigens. The latter group had a significantly reduced frequency of the antigen HLA\u2010A2 (13%) in comparison to the total patient population (49%). Use of donors whose HLA antigens are serologically cross\u2010reactive with those of alloimmunized patients provides approximately 10 times as many prospective donors as does selection based on matching for HLA and simplifies the procurement of hemostatically effective platelets for such patients.<\/jats:p>","DOI":"10.1002\/ajh.2830020303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:26:40Z","timestamp":1172032000000},"page":"219-226","source":"Crossref","is-referenced-by-count":185,"title":["Successful transfusion of platelets \u201cmismatched\u201d for HLA antigens to alloimmunized thrombocytopenic patients"],"prefix":"10.1002","volume":"2","author":[{"given":"Ren\u00e9 J.","family":"Duquesnoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn E.","family":"Rodey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred A.","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Aster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196911272812202"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1972.tb00059.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304122881504"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-1-9"},{"key":"e_1_2_1_6_2","first-page":"405","article-title":"Unrelated donors for bone\u2010marrow transplantation and transfusion support: pool sizes required","volume":"4","author":"Opelz O","year":"1974","journal-title":"Transpl Proc"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/219868a0"},{"key":"e_1_2_1_8_2","first-page":"79","volume-title":"Histocompatibility Testing","author":"Colombani J","year":"1970"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1399-0039.1974.tb00235.x","article-title":"Serological crossreactivity in the HLA system","volume":"2","author":"Mittal KK","year":"1974","journal-title":"Tissue Antigens"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1975.tb00588.x"},{"key":"e_1_2_1_11_2","first-page":"529","article-title":"The HL\u2010A system genetics and biological implications","volume":"78","author":"Dausset J","year":"1970","journal-title":"Acta Path Microbiol Scand"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197301000-00013"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1399-0039.1974.tb00234.x","article-title":"Effect of cross\u2010reactions on HLA antigen immunogenicity","volume":"4","author":"Colombani J","year":"1974","journal-title":"Tissue Antigens"},{"key":"e_1_2_1_14_2","unstructured":"RimmAA YahnkeD VieiraJ et al:Computer\u2010assisted storage and retrieval of HLA types for support of a histocompatible platelet transfusion program(to be submitted)."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197210000-00012"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1972.tb00123.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-0039.1976.tb01034.x","article-title":"Serological analysis of the HLA\u201010 complex","volume":"72","author":"Duquesnoy RJ","year":"1976","journal-title":"Tissue Antigens"},{"key":"e_1_2_1_18_2","first-page":"222","article-title":"Platelet and leukocyte isoantigens and their antibodies. 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