{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:37:21Z","timestamp":1760204241075},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the USA, erythrocytic glutathione reductase (GSSG\u2010R) deficiency is significantly more common, and can be considerably more pronounced in hospitalized patients (118\/3198) than in outpatients (37\/1639) or in apparently healthy persons (12\/849). Retrospective analysis of illnesses found in 118 inpatients with erythrocytic GSSG\u2010R deficiency revealed a striking and previously unsuspected association of the enzyme deficiency with a variety of chemotherapeutically treated hematological or nonhematological malignancies (51\/118 patients, 43.2%, or 51\/170 diagnoses, 30.0%). The prevalence of erythrocytic GSSG\u2010R deficiency also increased in malnutrition, liver disease, and sepsis. Drugs of the nitrosourea class, particularly BCNU [1, 3\u2010bis(2\u2010chloroethyl)\u20101\u2010nitrosourea] are causally implicated in the association of GSSG\u2010R deficiency with malignancies. Severe or complete GSSG\u2010R deficiency may handicap host response to infections.<\/jats:p>","DOI":"10.1002\/ajh.2830020402","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:22:57Z","timestamp":1172031777000},"page":"327-334","source":"Crossref","is-referenced-by-count":6,"title":["Erythrocytic glutathione reductase deficiency in a hospital population in the united states"],"prefix":"10.1002","volume":"2","author":[{"given":"Henri","family":"Frischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"603","article-title":"Erythrocytic glutathione reductase, glucose\u20106\u2010phosphate dehydrogenase, and 6\u2010phosphogluconic dehydrogenase deficiencies in populations of the United States, South Vietnam, Iran, and Ethiopia","volume":"81","author":"Frischer H","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","first-page":"613","article-title":"Visual test for erythrocytic glucose\u20106\u2010phosphate dehydrogenase, 6\u2010phosphogluconic dehydrogenase, and glutathione reductase deficiencies","volume":"81","author":"Frischer H","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(69)90282-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147797"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106162"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278653"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01769.x"},{"key":"e_1_2_1_9_2","first-page":"187","article-title":"Correlations between riboflavin supply, glutathione reductase activities and flavin levels in rats","volume":"43","author":"Glatzle D","year":"1973","journal-title":"Internat J Vit Nutr Res"},{"key":"e_1_2_1_10_2","unstructured":"FrischerH AhmadT: Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU [1 3\u2010bis(2 chloroethyl)\u20101\u2010nitrosourea].J Lab Clin Med in press 1977."},{"key":"e_1_2_1_11_2","first-page":"199","article-title":"Ulc\u00e8re sur atrophie blanche: an\u00e9mie h\u00e9molytique d\u00e9clench\u00e9e par la disulfone r\u00e9v\u00e9latrice d'un d\u00e9ficit \u00e9rythrocytaire en glutathion r\u00e9ductase","volume":"79","author":"Dugois P","year":"1972","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"e_1_2_1_12_2","first-page":"347","article-title":"Glutathionreduktase\u2010Mangel bei Dermatitis herpetiformis Duhring","volume":"24","author":"Ben\u00f6hr HCh","year":"1973","journal-title":"Der Hautarzt"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(61)90047-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0550400"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001617"},{"key":"e_1_2_1_16_2","first-page":"38","volume-title":"Analysing qualitative data","author":"Maxwell AE","year":"1961"},{"key":"e_1_2_1_17_2","first-page":"239","article-title":"Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism","volume":"24","author":"Pritcher CS","year":"1963","journal-title":"Clin Sci"},{"key":"e_1_2_1_18_2","first-page":"552","article-title":"Etudes sur l'an\u00e9mie des cirrhoses. 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