{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:53:03Z","timestamp":1771005183226,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The first case of Hb Leiden (\u03b1<jats:sub>2<\/jats:sub>\u03b2<jats:sub>2<\/jats:sub> <jats:sup>6 or 7 Glu\u21920<\/jats:sup>)\u2010\u03b2\u00b0 thalassemia in a young patient with chronic severe hemolytic anemia, which improved after splenectomy, is described. His parents were Chinese. The patient's blood showed no Hb A or normal \u03b2 chains when no blood transfusion was given. His mother was heterozygous for \u03b2\u00b0 thalassemia, and his father and brother had the trait for the unstable Hb Leiden. The Hb Leiden level of the father was 22.6% and that of the brother was 19.3%. It is probable that the abnormal hemoglobin in this Chinese family resulted from an independent gene mutation, unrelated to the one found in 2 Caucasian families reported earlier.<\/jats:p>","DOI":"10.1002\/ajh.2830020403","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:22:57Z","timestamp":1172031777000},"page":"335-342","source":"Crossref","is-referenced-by-count":11,"title":["Hb leiden\u2010\u03b2\u00b0 thalassemia in a chinese with severe hemolytic anemia"],"prefix":"10.1002","volume":"2","author":[{"given":"Luan Eng","family":"Lie\u2010Injo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. I.","family":"Randhawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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