{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:14:39Z","timestamp":1790806479643,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":13296,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following extensive bowel resection, a young woman experienced severe malnutrition; subsequent administration of parenteral nutrition precipitated the copper deficiency syndrome. This consisted of hypocupremia, subnormal ceruloplasmin levels, anemia, and severe neutropenia. The bone marrow was megaloblastic, vacuolated, and sideroblastic; granulocytic maturation was not observed beyond the myelocyte stage. Copper sulfate therapy was followed by a marked reticulocytosis, increase in hematocrit, and recovery of neutrophils.<\/jats:p><jats:p>Additional studies indicated that both serum and urinary erythropoietin values were low; serum activity increased after copper supplementation. Abnormal granulopoiesis was demonstrated using the in vitro granulocyte colony assay. The patient's granulocytic stem cells were normal on two occasions; however, mixing studies showed that culture of the patient's copper\u2010deficient marrow with her copper\u2010deficient serum yielded significantly reduced numbers of granulocyte colonies. Thus, copper appears to be a necessary element for normal hematopoiesis; lack of this trace element may result in ineffective erythropoiesis and granulopoiesis.<\/jats:p>","DOI":"10.1002\/ajh.2830030209","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T16:44:41Z","timestamp":1369759481000},"page":"177-185","source":"Crossref","is-referenced-by-count":82,"title":["Observations on the anemia and neutropenia of human copper deficiency"],"prefix":"10.1002","volume":"3","author":[{"given":"Bernard L.","family":"Zidar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Shadduck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zella","family":"Zeigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Winkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1542\/peds.34.3.324","article-title":"Copper deficiency in the malnourished infant","volume":"34","author":"Cordano A","year":"1964","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_2","first-page":"139","article-title":"Copper depletion and deficiency in the malnourished infant","volume":"124","author":"Graham GG","year":"1969","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V28.2.280.280"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110072851506"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1542\/peds.52.4.525","article-title":"The syndrome of neonatal copper deficiency","volume":"52","author":"Ashkenazi A","year":"1973","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80449-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-4-470"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197407252910407"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410102911526"},{"key":"e_1_2_1_11_2","first-page":"722","article-title":"Hormone and amino acid levels in altered nutritional states","volume":"76","author":"Adibi SA","year":"1970","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","first-page":"141","article-title":"More on trace elements in total parenteral nutrition solutions","volume":"32","author":"Shils ME","year":"1975","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_1_13_2","first-page":"249","volume-title":"Hemopoietic Cellular Proliferation","author":"Robinson WA","year":"1970"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3946.691"},{"key":"e_1_2_1_15_2","first-page":"657","article-title":"Standardized bioassay for bone marrow colony stimulating factor in human urine: Levels in normal man","volume":"79","author":"Stanley ER","year":"1972","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-122-31246"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-128-32961"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood.V28.3.344.344","article-title":"Urinary excretion of erythropoietin in normal men and women","volume":"28","author":"Alexanian R","year":"1966","journal-title":"Blood"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/48.3.286"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-104-25928"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/jn\/50.4.395","article-title":"Studies on the function and metabolism of copper","volume":"50","author":"Wintrobe MM","year":"1953","journal-title":"J Nutr"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35813"},{"key":"e_1_2_1_23_2","first-page":"174","article-title":"Studies on erythropoietin III. 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