{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:50:02Z","timestamp":1784335802861,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A role for coagulation in the pathogenesis of sickle cell anemia (SCA) pain crisis has long been suspected. We have observed evidence for in vivo coagulation in patients with SCA during pain crisis utilizing a radioimmunoassay for fibrinopeptide A (FPA). Since the proteolytic activity of thrombin results in the release of FPA from fibrinogen, plasma levels of FPA may be used as an index of in vivo thrombin activity. In 20 normal controls FPA plasma levels had a range of 0.6\u20131.4 ng\/ml and a mean of 0.7 \u00b1 0.2 ng\/ml. We observed elevations of FPA, values greater than the mean plus 4 standard deviations of the control group, in 21 consecutive plasma samples obtained from 8 SCA patients during pain crisis. FPA determinations on 7 of 10 plasma specimens obtained from 10 SCA patients during pain\u2010free periods were within the normal range. Elevations of FPA in 2 of 3 of these pain\u2010free patients could be explained by recent extensive oral surgery and faulty venopuncture, conditions known to cause elevated levels of the peptide. Plasma specimens were obtained from 2 SCA patients patients with subjective complaints of pain, but who were suspected of malingering prior to FPA determination. In both instances, FPA was within the normal range.<\/jats:p><jats:p>In summary, plasma levels of FPA appear to be elevated in SCA patients during crisis as contrasted to pain\u2010free periods and normal controls. This study provides new evidence for the occurrence of intravascular coagulation during SCA pain crisis. Further studies are needed to assess whether this activation of the coagulation system is a cause or an effect of pain crisis.<\/jats:p>","DOI":"10.1002\/ajh.2830050303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:13:47Z","timestamp":1172034827000},"page":"183-190","source":"Crossref","is-referenced-by-count":24,"title":["Elevated plasma levels of fibrinopeptide a during sickle cell anemia pain crisis\u2013evidence for intravascular coagulation"],"prefix":"10.1002","volume":"5","author":[{"given":"David A.","family":"Leichtman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.133.4.635"},{"key":"e_1_2_1_3_2","first-page":"44","article-title":"Platelet function and survival in sickle cell disease","volume":"82","author":"Haut MJ","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_4_2","first-page":"440","article-title":"Hemostatic alterations accompanying sickle cell pain crisis","volume":"88","author":"Alkjaersig N","year":"1966","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0520200"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.10.2350"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107749"},{"key":"e_1_2_1_8_2","first-page":"608","volume-title":"Handbook of Experimental Immunology","author":"Hunter WM","year":"1967"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(76)90265-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197211162872001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1182\/blood.V45.6.757.757","article-title":"Reaction of plasmic degradation products of fibrinogen in the radioimmunoassay of human fibrinopeptide A","volume":"45","author":"Brudzynski AZ","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5566.653"},{"key":"e_1_2_1_13_2","first-page":"10","volume-title":"Impaired fibrinolysis in sickle cell disease. Relation to crisis and infection","author":"Green D","year":"1970"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-23-3-376"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196307252690403"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91498-5"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.2830050303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.2830050303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:24:44Z","timestamp":1699831484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.2830050303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1002\/ajh.2830050303"],"URL":"https:\/\/doi.org\/10.1002\/ajh.2830050303","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}