{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T13:10:20Z","timestamp":1699881020144},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete potentiation of vincristine cytotoxicity comparable to that achieved by the addition of prednisolone was observed when the latter drug was replaced by a variety of mineralocorticoids (aldosterone, desoxycorticosterone and fludrocortisone), glucocorticoids (hydrocortisone, dexamethasone), androgens (testosterone, methyltestosterone, androsterone, dehydroepiandrosterone, etiocholanolone), estrogens (estrone, 17\u2010\u03b2estradiol) and progestins (progesterone, pregnanediol). No potentiation of cytotoxicity was observed when nonsteroidal hormones (thyroxin, ACTH) were added to vincristine. It is concluded that a wide variety of compounds with the basic perhydrocyclopentano\u2010phenanthrene nucleus of the steroid molecule are capable of enhancing the cytotoxicity achieved with vincristine.<\/jats:p>","DOI":"10.1002\/ajh.2830050405","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:12:49Z","timestamp":1172034769000},"page":"305-314","source":"Crossref","is-referenced-by-count":1,"title":["Potentiation of vincristine cytotoxicity by hormones: Corticosteroids, androgens, estrogens and progestins"],"prefix":"10.1002","volume":"5","author":[{"given":"Fred","family":"Rosner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashar","family":"Hirshaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans W.","family":"Gr\u00fcnwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"700","article-title":"In vitro combination chemotherapy demonstrating potentiation of vincristine cytotoxicity by prednisolone","volume":"35","author":"Rosner F","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830040106"},{"key":"e_1_2_1_4_2","volume-title":"A two dimensional model of combination chemotherapy in vitro. 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Sao Paulo Brazil July 16\u201321 1972. Program XIV Congress Intern Soc Hemat Abstract No. 510."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5905.409"},{"key":"e_1_2_1_12_2","first-page":"33","volume-title":"Cancer Chemotherapy","author":"Marsden JH","year":"1972"},{"key":"e_1_2_1_13_2","first-page":"455","article-title":"Historical background of vinca alkaloid research and areas of future interest. 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