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The patient's serum also showed a severe deficiency of IgG, no detectable IgA, IgM, or IgD, and increased IgE. The chemotactic defect was shown to be due to a cell\u2010directed inhibitor in the patient's serum. The effect of the inhibitor on chemotaxis could be antagonized by factors in normal serum. The chemotaxis defect persisted for several months, but eventually returned to normal.<\/jats:p>","DOI":"10.1002\/ajh.2830050410","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:12:49Z","timestamp":1172034769000},"page":"347-353","source":"Crossref","is-referenced-by-count":0,"title":["An acquired cell\u2010directed inhibitor of neutrophil chemotaxis and hypogammaglobulinemia"],"prefix":"10.1002","volume":"5","author":[{"given":"Dennis A.","family":"Casciato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry C.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90354-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5775.617"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.1.68"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.92.1.145","article-title":"Studies on heat\u2010labile opsonin in rabbit serum","volume":"92","author":"Hirsch JG","year":"1964","journal-title":"J Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.124.3.483"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1955.tb45983.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(75)90142-8"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"A new familial defect of neutrophil movement","volume":"82","author":"Miller ME","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.3.453"},{"key":"e_1_2_1_11_2","first-page":"59","article-title":"Pathology of chemotaxis and random mobility","volume":"12","author":"Miller ME","year":"1975","journal-title":"Semin Hematol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-4-414"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4049\/jimmunol.114.2_Part_2.843","article-title":"Two distinct chemotactic inactivators in normal serum","volume":"114","author":"Till G","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230145"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4049\/jimmunol.107.1.317.a","article-title":"Inhibition of chemotaxis by human leukocytes following incubation in homologous serum devoid of chemotactic activity","volume":"107","author":"Miller ME","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.124.2.209"},{"key":"e_1_2_1_17_2","first-page":"190","article-title":"Partial characterization of a cell directed inhibitor of leukotaxis in human serum","volume":"89","author":"Maderazo EG","year":"1977","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_2","first-page":"227","volume-title":"The Phagocytic Cell in Host Resistance","author":"Gallin JI","year":"1975"},{"key":"e_1_2_1_19_2","first-page":"939","article-title":"Intrinsic defect of the polymorphonuclear leukocyte resulting in impaired chemotaxis and phagocytosis","volume":"9","author":"Steerman RL","year":"1971","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80903-6"},{"key":"e_1_2_1_21_2","first-page":"249","volume-title":"The Phagocytic Cell in Host Resistance","author":"Hill HR","year":"1975"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107784"},{"key":"e_1_2_1_23_2","first-page":"304","article-title":"Immunoglobulin E in immunologic deficiency diseases. 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