{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:10:30Z","timestamp":1699841430147},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":10022,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ratio of G\u03b3 to A\u03b3 chains was studied in 13 normal healthy newborns and in eight neonates with hydrops fetalis due to homozygous \u03b1\u2010thalassemia. The findings in the normal healthy newborns agreed with those of earlier reports. In homozygous \u03b1\u2010thalassemia the G\u03b3 and A\u03b3 ratio appeared generally lower than in healthy control newborns, but one of the hydrops fetalis cases had a very high G\u03b3 value.<\/jats:p><jats:p>In all 13 normal healthy newborns, in 8 patients with homozygous \u03b1\u2010thalassemia, and in 4 patients with homozygous \u03b2\u2010thalassemia, T\u03b3 chains with threonine at position 75 were detected in addition to I\u03b3 chains with isoleucine at position 75. In homozygous \u03b1\u2010thalassemia, the T\u03b3\u2010to\u2010I\u03b3 ratio seemed lower and in homozygous \u03b2\u2010thalassemia higher than in normal newborns.<\/jats:p>","DOI":"10.1002\/ajh.2830060104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T05:13:01Z","timestamp":1172034781000},"page":"17-25","source":"Crossref","is-referenced-by-count":1,"title":["Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia"],"prefix":"10.1002","volume":"6","author":[{"given":"Luan Eng","family":"Lie\u2010Injo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. I.","family":"Randhawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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